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Diss Factsheets
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EC number: 200-849-9 | CAS number: 75-21-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Publication describes investigation of many substances and the procedures are generally described with indication of exemptions in some cases. These cases are not specified so that it is not possible to definately retrace the conditions for one specific substance.
Data source
Reference
- Reference Type:
- publication
- Title:
- The single dose toxicity of some glycols and derivatives.
- Author:
- Smyth H.F. Jr., Seaton J. and Fischer L.
- Year:
- 1 941
- Bibliographic source:
- Journal of Industrial Hygiene and Toxicology 23, 259 - 268
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- less reporting destails. Body weights not reported. Only males examined.
- GLP compliance:
- no
- Test type:
- fixed dose procedure
Test material
- Reference substance name:
- Ethylene oxide
- EC Number:
- 200-849-9
- EC Name:
- Ethylene oxide
- Cas Number:
- 75-21-8
- Molecular formula:
- C2H4O
- IUPAC Name:
- oxirane
Constituent 1
- Specific details on test material used for the study:
- Commercial grade
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Commercial breeders
- Weight at study initiation: 250-300 g
- Diet: ad libitum. Diet was given in the afternoon, doses the following morning.
- Water: ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Any victim whose death was inconsistent with the indications from others receiving the substance was atopsied, and if found to be infected it was not included in the calculations. Tissues were not studied microscopically because this step was beyond the scope of the preliminary investigation planned.
The data were calculated by method of probits, described by Bliss (1935) and now becoming familiar. No attempt was made to use adequate animals to obtain extreme precision in the LD50 figure, for the use to which such information is put seldom justified extreme accuracy. The precision is indicated by the range of 95% probability. - Doses:
- Max concentration fed: 1%
The exact dosages were not reported. Enough dosages were administered to include those at which no animal died and those at which all died. Most deaths occurred with the first 2 days, but all deaths within 14 days of administration of the dose were considered in calculating the LD50. - No. of animals per sex per dose:
- Indicated to be generally 10
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 330 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 290 - < 360
- Mortality:
- Death was delayed about a week; and if deaths only within the first 2 days had been considered, the LD50 reported would usually have been much higher.
- Clinical signs:
- other: Fatal or near fatal doses produced no narcosis but varying degrees of sluggish depressed functioning. The test substance caused narcosis but in most cases only at the LD50 or above.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- In summary, male rats were exposed to concentrations of up to 1% resulting in an LD50 of 330 mg/kg bw.
- Executive summary:
An acute oral toxicity study was conducted using ten male Wistar rats exposed to concentrations of 1% as a maximum using the fixed dose procedure. A 14-day observation period was performed and necropsy and clinical signs were performed. Death was delayed about a week; and if deaths only within the first 2 days had been considered, the LD50 reported would usually have been much higher. Fatal or near fatal doses produced no narcosis but varying degrees of sluggish depressed functioning. The test substance caused narcosis but in most cases only at the LD50 or above. The LD50 was reported to be 330 mg/kg bw.
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