Registration Dossier
Registration Dossier
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EC number: 201-177-9 | CAS number: 79-10-7
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 995
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Flow-through in vitro skin penetration chamber method according to Frantz et el. (1990).
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Acrylic acid
- EC Number:
- 201-177-9
- EC Name:
- Acrylic acid
- Cas Number:
- 79-10-7
- Molecular formula:
- C3H4O2
- IUPAC Name:
- prop-2-enoic acid
- Details on test material:
- - Name of test material (as cited in study report): Acrylic acid
- Analytical purity: > 98 % (unlabeled AA)
- Supplier: Union Carbide Corporation
- Radiochemical purity (if radiolabelling): >= 98.6 %
- Specific activity (if radiolabelling): 0.14 - 0.4 mCi/mmol
- Locations of the label (if radiolabelling): [1-14C]AA
- Supplier: Sigma Chemical Co. (St. Louis, Mo.)
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Acrylic acid
- Analytical purity: > 98 % (unlabeled AA)
- Supplier: Union Carbide Corporation
- Radiochemical purity (if radiolabelling): >= 98.6 %
- Specific activity (if radiolabelling): 0.14 - 0.4 mCi/mmol
- Locations of the label (if radiolabelling): [1-14C]AA
- Supplier: Sigma Chemical Co. (St. Louis, Mo.) - Radiolabelling:
- yes
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratories (Kingston, NY)
- Substrain: F344/NHsd
- Age at study initiation: approx. 7 wk old
- Weight at study initiation: 210 g
- Diet (ad libitum): Agway Prolab Diet Rat, Agway Inc., Syracuse, NY
- Water (ad libitum)
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- acetone
- Duration of exposure:
- 6 hrs
- Control animals:
- no
- Details on in vitro test system (if applicable):
- SKIN PREPARATION
- Source of skin: dorsal skin from male rats (hair clipped)
PRINCIPLES OF ASSAY
- Diffusion cell: flow-through diffusion cell (Frantz cell)
- Flow-through system: yes
- Test temperature: 32 °C
- Occlusion: no
Results and discussion
- Absorption in different matrices:
- Over a 6-h period, 23.9 ± 5.4% (mean ± SD, n= 3) of the dose was absorbed into the effluent or was found in the skin. At least 60% of the dose evaporated, and total recovery of the applied dose was about 85%.
- Total recovery:
- 85 %
Any other information on results incl. tables
The results from the in vitro experiment supported those of the in vivo study (see 7.1.1).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
