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Diss Factsheets
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EC number: 201-202-3 | CAS number: 79-39-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Japanese government peer-reviewed the documents, audited selected studies.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Supplier: KISHIDA CHEMICALS CO.
Ltd (Lot No. D12358J)
Purity: >= 98 % - Analytical monitoring:
- yes
- Remarks:
- measuerd by GC
- Vehicle:
- no
- Test organisms (species):
- Oryzias latipes
- Details on test organisms:
- Test Organism:
-supplier: Aichi Yatomi chiku fish farm (Aichi, Japan)
-size/weight: 21.2 mm (18.7 - 22.9 mm),
n= 10/0.1392 g (0.0913 - 0.1855 g),
n= 10 -feeding during acclimation: "TETRAMIN"
-acclimation: acclimated to dilution water for more than 12 days before testing
-feeding during test: none, feeding was stoped before 24 hr of the test
STOCK AND TEST SOLUTION AND THEIR PREPARATION:
-solvent: no solvent was used
-stock of solution: no data - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 41.0 mg/L as CaCO3
- Test temperature:
- 23.1 - 23.8 °C
- pH:
- 6.9 - 7.0
- Dissolved oxygen:
- 6.4 - 11.3 mg/L
- Nominal and measured concentrations:
- Measured concentrations: 0 and 100 mg/L nominal concentration (actual concentration measured and greater than 80% of the nominal concentration):
Results:
Table 1 NOMINAL/MEASURED CONCENTRATION:
-----------------------------------------------------------
Nominal Measured conc. (mg/L)
conc (% of nominal)
(mg/L) 0 hr* 24 hr** mean
-----------------------------------------------------------
Control <0.5 <0.5
100 mg/L 90.5 (90.5) 94.4 (94.4) 92.4
-----------------------------------------------------------
* : freshly prepared test solution
**: test solution after 24 hr exposure period
EFFECT OF MORTALITY: none at control and 100 mg/L
SYMPTOMS: none of abnormalities at control and 100 mg/L - Details on test conditions:
- DILUTION WATER:
-source: dechlorinated tap water
-aeration: no data
-hardness: 41.0 mg/L as CaCO3
-pH: 6.8
TEST SYSTEM
-concentration: 0, 100 mg/L
-detail test method: semi-static, open system
-renewal of test solution: 24 hr
-exposure vessel type: 3L glass vessel
-number of replicates/fish per replicate: 1/10
-test temperature: 23 - 25 °C
-intensity of irradiation: room light
-photoperiod: 16 hr - 8 hr light-dark cycle
TEST PARAMETER: mortality, abnormal behavior and abnormal respiration
SAMPLING: at 0 and 24 hr
MONITORING OF TEST SUBSTANCE CONCENTRATION: measured by GC - Reference substance (positive control):
- yes
- Remarks:
- CuSO4-5H2O
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- EFFECT OF MORTALITY: none at control and 100 mg/L
SYMPTOMS: none of abnormalities at control and 100 mg/L - Results with reference substance (positive control):
- - Results with reference substance valid?
- Mortality:
- LC50: 0.59 mg/L (96 h) - Reported statistics and error estimates:
- Statistics: no data
- Validity criteria fulfilled:
- yes
- Conclusions:
- At a limit concentration of 100 mg/l (nomial), methacrylamide showed no mortality in a semistatic acute fish toxicity test OECD 203 with oryzias latipes.
LC50 (96h) > 100 mg/l (nominal)
Methacrylamide would be classified as not acute toxic to fish in accordance with CLP regulation - Executive summary:
In a 96-h acute toxicity study, Medaka (Oryzias latipes) were exposed to methacrylamide at nominal concentrations of > 100 mg/l without solvent under semistatic conditions. The 96-h LC50 was > 100 mg/l.
Based on the results on this study, methacrylamide would be classified as not acute toxic to fish in accordance with th classification CLP regulation.
This toxicity study is classified as acceptable and satifies the guideline for Fish, acute toxicity study (OECD 203)
Results Synopsis
Test organism size/age: mean length: 21.2mm; mean weight: 0.1392 g (n=10)
Test type: semistatic
LC50: > 100 mg/l measured/nominal
LC0: > 100 mg/l measured/nominal
LC100: > 100 mg/l measured/nominal
Endpoints effected: mortality, abnormal behavoir, abnormal respiration
Reference
Description of key information
In a 96-h acute toxicity study, Medaka (Oryzias latipes) were exposed to methacrylamide at nominal concentrations of > 100 mg/l without solvent under semistatic conditions. The 96-h LC50 was > 100 mg/l.
Based on the results on this study, methacrylamide would be classified as not acute toxic to fish in accordance with EU regulation No. 1272/2008 (CLP regulation).
This toxicity study is classified as acceptable and satifies the guideline for Fish, acute toxicity study (OECD 203)
LC50: > 100 mg/l measured/nominal
LC0: > 100 mg/l measured/nominal
LC100: > 100 mg/l measured/nominal
Endpoints effected: mortality, abnormal behavior, abnormal respiration
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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