Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-081-7 | CAS number: 78-08-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
The registered substance triethoxy(vinyl)silane (CAS No. 78-08-0) hydrolyses rapidly in contact with water (DT50 = 0.9 h at pH 7 and 20 – 25 °C, QSAR) to vinylsilanetriol and ethanol. REACH guidance R.16 states that “for substances where hydrolytic DT50 is less than 12 h, environmental effects are likely to be attributed to the hydrolysis product rather than to the parent itself” (ECHA, 2016). TGD (EC, 2003) and REACH guidance R.16 (ECHA, 2016) also suggest that when the hydrolysis half-life is less than 12 h, the breakdown products, rather than the parent substance, should be evaluated for aquatic toxicity testing.
Because there is no data available on the aquatic toxicity of the registered substance or its silanol hydrolysis product, the aquatic toxicity was assessed based on read-across to a structural similar analogue substance trimethoxy(vinyl)silane (CAS No. 2768-02-7). The source substance hydrolyses rapidly in the aquatic environment (DT50 = 0.1 h at 20 -25 °C and pH 7, QSAR) to form the same silanol hydrolysis product as the target substance, vinylsilanetriol, and the alcohol hydrolysis product methanol instead of ethanol, which is formed as the second hydrolysis product of the target substance. Additional information is given in a read-across justification attached in IUCLID section 13.
Acute toxicity studies evaluating the short-term toxicity of the source substance to aquatic organisms are available for all three trophic levels. All studies were performed according to accepted standard guidelines and GLP. No acute effects were observed towards the tested organisms of all three trophic levels up to the highest concentration tested. Chronic toxicity data of the source substance is available for aquatic invertebrates and algae. In Algae no effects were seen up to the highest tested concentration. For aquatic invertebrates a 21-day NOEC of 28.1 mg/L (measured, time-weighted average) was obtained.
For the toxicity in aquatic microorganism, data was read across for the source substance of a reliable biodegradation study conducted according to OECD 301 F and GLP conditions. The biodegradation rate in the toxicity control shows a similar course of biodegradation as the two controls containing the reference item only. Within 14 days of exposure, a biodegradation of 64 % was observed. Thus, according to guideline the test item shows no inhibitory effect on activated sludge microorganisms up to a concentration of 100 mg/L. The NOEC of 100 mg/L can be used for the PNEC derivation. On this basis, no toxic effects are anticipated by the target substance and the degradation process in sewage treatment plants is not considered to be inhibited.
The second hydrolysis products of source and target substance methanol and ethanol are well characterised in the public domain literature and is not hazardous at the concentrations relevant to the studies. The short-term EC50 and LC50 values for both alcohol hydrolysis products are in excess of 1000 mg/l (see Table 1) (OECD SIDS, 2004; OECD SIDS, 2004). Thus, methanol and ethanol are not considered to contribute to the overall aquatic toxicity of the source and target substance, respectively. In consequence, data for the alcohol hydrolysis products are not presented specifically for each environmental toxicity endpoint within this dossier.
Table 1: Overview on aquatic effect values for Triethoxy(vinyl)silane and its hydrolysis products.
|
Source |
Parent |
Silanol hydrolysis product |
Other hydrolysis product* |
|
|
|
|
|
Source |
Parent |
CAS |
2768-02-7 |
78-08-0 |
|
67-56-1 |
64-17-5 |
|
Trimethoxy(vinyl)silane |
Triethoxy(vinyl)silanol |
vinylsilanetriol |
Methanol |
Ethanol |
Acute fish (LC50) |
> 100 mg/L |
RA CAS 2768-02-7 |
RA CAS 2768-02-7 |
> 15000 mg/L |
> 1100 mg/L |
Acute Invertebrates (EC50) |
168.7 mg/L |
RA CAS 2768-02-7 |
RA CAS 2768-02-7 |
>10000 mg/L |
12340 mg/L |
Chronic aquatic invertebrates (NOEC) |
28.1 mg/L |
RA CAS 2768-02-7 |
RA CAS 2768-02-7 |
No data |
No data |
Algae (ErC50) |
> 89 mg/L |
RA CAS 2768-02-7 |
RA CAS 2768-02-7 |
Ca. 22000 mg/L |
10000 mg/La |
Algae (NOErC) |
89 mg/L |
RA CAS 2768-02-7 |
RA CAS 2768-02-7 |
No data |
No data |
Toxicity to microorganisms (NOEC) |
100 mg/L |
RA CAS 2768-02-7 |
RA CAS 2768-02-7 |
No data |
6500 mg/Lb |
* Source = OECD SIDS (2004)
a: 96-h EC50 for Selenastrum capricornumtum also known as Pseudokirchneriella subcapitata
b: 16-hour toxicity threshold using Pseudomonas putida
References:
OECD SIDS, 2004. Ethanol - SIDS Initial Assessment Report For SIAM 19, Berlin, Germany: UNEP Publications.
OECD SIDS, 2004. Methanol - SIDS Initial Assessment Report For SIAM 19, Berlin, Germany: UNEP Publications.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.