Registration Dossier
Registration Dossier
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EC number: 451-490-1 | CAS number: -
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
The test substance is hydrolitically stable.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 96 d
- at the temperature of:
- 25 °C
Additional information
In a GLP-compliant study according to OECD guideline 111, hydrolysis of the test substance was tested at varying temperatures and as a function of pH (RCC, 2005).
In a pre-test the hydrolysis of the test item was investigated at 50.0 °C at each of pH 4.0, pH 7.0 and pH 9.0. The test substance was found to be stable at pH 7.0 and 50 °C. Therefore no further testing was performed at this pH-value. As in the pre-test the test substance was not stable at pH 4.0 and at pH 9.0, further testing was performed at elevated temperatures. The rate constant and half-life times of hydrolysis at 25 °C were calculated from the data generated at the varying pH and temperatures.
The test substance was stable at pH 7.0, the calculated half-life at 25 °C being more than one year. At pH 4.0 and pH 9.0 the calculated half-lifes at 25 °C were 95457 hours (3977 days) and 2298 hours (96 days), respectively. Based on these data the substance should be considered hydrolytically stable.
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