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EC number: 436-060-3 | CAS number: - FC 84508 PK
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From Jan. 08, 2003 to Feb. 14, 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
- Radiolabelling:
- no
- Test temperature:
- 25 °C
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: HPLC pump G1311A, autosampler G1313A, column oven G1316A, degaser (G1322A)
- Type, material and dimension of analytical (guard) column: Stationary phase
- Detection system: UV/VlS detector G1314A by Agilent
- Flow rate: 1 mL/min
MOBILE PHASES
- Type: acetonitrile / cleaned water, isocratic elution: 60 : 40 % (v/v)
- Experiments with additives carried out on separate columns: yes
DETERMINATION OF DEAD TIME
- Method: The dead time was determined by using a "dead time marker". Dead time markers are substances which are not retarded from column or mobile phases.
REFERENCE SUBSTANCES
- Identity: Benzamide, 2-Nitrobenzamide, N, N-Dimethylbenzamide, Manuran, Triadimenol, Linuron, 1,2,3-Trichlorobenzene, Pyrazophos, Diclofop-methyl
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: 0.31 µg
- Quantity of reference substances: 0.92-1.27 µg
- For calibration the retention times of a series of substances with known adsorption coefficients were measured and a calibration graph was established
REPETITIONS
- Number of determinations: Two
EVALUATION
- Calculation of capacity factors k': Yes
- Calculation of retention times: Yes
- Determination of the log Koc value: Yes - Computational methods:
- Not applicable
- Type:
- log Koc
- Value:
- 4.36 dimensionless
- Temp.:
- 25 °C
- Remarks on result:
- other: extrapolated
- Key result
- Type:
- log Koc
- Value:
- > 4.2 dimensionless
- Temp.:
- 25 °C
- Remarks on result:
- other: ( 25 °C is column temperature)
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration: 6.86- 6.87 min
- Details of fitted regression line (log k' vs. log Koc): Measurement 1 & 2: 0.09 vs. 4.36; - Transformation products:
- no
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the test conditions, the adsorption coefficient (log Koc) of the test substance was determined to be >4.2
- Executive summary:
A study was performed to determine the adsorption coefficient (log Koc) of the test substance according to EU Method C.19. and OECD Guideline 121 in compliance with GLP.
Test was conducted using HPLC method. The dead time was determined by using a "dead time marker". For calibration the retention times of a series of substances with known adsorption coefficients were measured and a calibration graph was established. The adsorption coefficient of the test substance was derived from its retention time and the calibration graph. The calibration substances were injected in two series and one before and one after the injection of the test substance.
The dead time was determined to be 3.07 min and log Koc of the test substance at two measurements was 4.36.
Under the test conditions, the adsorption coefficient (log Koc) of the test substance was determined to be >4.2.
Reference
Table 1. log Koc of the test substance.
|
tR in min |
K |
Log k |
log koc |
Measurement 1 |
6.87 |
1.24 |
0.09 |
4.36 |
Measurement 2 |
6.86 |
1.23 |
0.09 |
4.36 |
Description of key information
The adsorption coefficient (log Koc) of the test substance was determined to be > 4.2 using HPLC method.
Key value for chemical safety assessment
- Koc at 20 °C:
- 4.4
Additional information
A study was performed to determine the adsorption coefficient (log Koc) of the test substance according to EU Method C.19. and OECD Guideline 121.
Test was conducted using HPLC method. The dead time was determined by using a "dead time marker". For calibration the retention times of a series of substances with known adsorption coefficients were measured and a calibration graph was established. The adsorption coefficient of the test substance was derived from its retention time and the calibration graph. The calibration substances were injected in two series and one before and one after the injection of the test substance.The dead time was determined to be 3.07 min and log Koc of the test substance at two measurements was 4.36. The adsorption coefficient (log Koc) of the test substance was determined to be >4.2, with 4.2 being the adsorption coefficient of the highest calibration standard. (Schminke A, 2003)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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