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EC number: 232-455-8 | CAS number: 8042-47-5 A highly refined petroleum mineral oil consisting of a complex combination of hydrocarbons obtained from the intensive treatment of a petroleum fraction with sulfuric acid and oleum, or by hydrogenation, or by a combination of hydrogenation and acid treatment. Additional washing and treating steps may be included in the processing operation. It consists of saturated hydrocarbons having carbon numbers predominantly in the range of C15 through C50.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 1985-02-11 to 1985-03-04
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable without restriction because it was conducted similar to OECD guideline 403 and GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 8042-47-5
- Cas Number:
- 8042-47-5
- IUPAC Name:
- 8042-47-5
- Reference substance name:
- Highly refined base oil
- IUPAC Name:
- Highly refined base oil
- Test material form:
- other: Oily liquid
- Details on test material:
- - Name of test material (as cited in study report): F-52-01
- Physical state: transparent colorless liquid
- Purity: 100% petroleum hydrocarbons
- Density: 0.8433 g/mL
- Lot/batch No.: 769
- Expiration date of the lot/batch: September 1989
- Storage condition of test material: Temperature-monitored room, out of direct light and away from radiation sources
- Other: Flash point is 355 degrees fahrenheit
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD(SD)BR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Canada, Inc., St. Constant, Quebec, Canada
- Age at study initiation: 8 to 12 weeks old
- Weight at study initiation: 216 to 240 grams
- Fasting period before study: not reported
- Housing: individually housed in stainless steel, wire mesh-bottom cages
- Diet (e.g. ad libitum): ad libitum except during 4-hour exposure period
- Water (e.g. ad libitum): ad libitum except during 4-hour exposure period
- Acclimation period: not reported
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20.6 to 22.2°C
- Humidity (%): 33 to 72%
- Air changes (per hr): not reported
- Photoperiod (hrs dark / hrs light): not reported
IN-LIFE DATES: From: 1985-02-11 To: 1984-03-04
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: 27" cubed stainless steel whole-body exposure chamber
- Exposure chamber volume: 400 litres
- Method of holding animals in test chamber: none
- Source and rate of air: 45 L/min
- Method of conditioning air: not reported
- System of generating particulates/aerosols: Thermo Systems Inc. 6-jet atomizer supplied with pre-dried compressed air
- Method of particle size determination: Andersen 1 ACFM Ambient sampler
- Treatment of exhaust air: passed through HEPA filter and activated charcoal filter before release
- Temperature, humidity, pressure in air chamber: 21.1 celsius average temperature, 63.5% average humidity, pressure not reported
TEST ATMOSPHERE
- Brief description of analytical method used: gravimetric analysis
- Samples taken from breathing zone: yes
- Particle size distribution: not reported
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): 2.7 micrometres / 2.2 micrometres - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 5 mg/L
- No. of animals per sex per dose:
- 5 animals per sex per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed prior to exposure, hourly during exposure, hourly for four hours following exposure, and twice daily during the remainder of the 14-day exposure period. Animals were weighed upon receipt at the research facility, on the day of treatment prior to exposure, and on days 7 and 14 of the study.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs were noted
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- No mortality was observed during the study period.
- Clinical signs:
- other: Clinical signs included labored breathing, rales, partial closing of the eyes, nasal discharge, recumbency, and incoordination. All animals appeared normal at day 5 after exposure and throughout the remainder of the study period.
- Body weight:
- Four of five females had transient weight loss during the first week of observation.
- Gross pathology:
- No pathological observations were noted.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LC50 of Highly refined base oil aerosol administered to rats is greater than 5 mg/L. This dose level is not classifiable according to EU guidelines.
- Executive summary:
In an acute inhalation study, Highly refined base oil was administered to Crl:CD(SD)BR rats (5/sex) via whole-body exposure at a dose level of 5 mg/L for 4 hours. Animals were observed for 14 days post exposure.
No mortality was observed. Clinical signs included laboured breathing, rales, partial closing of the eyes, nasal discharge, recumbency, and incoordination. All animals appeared normal at day 5 after exposure and throughout the remainder of the study period. Four of five females had transient weight loss during the first week of observation. The LC50 of Highly refined base oil aerosol administered to rats is greater than 5 mg/L. This dose level is not classifiable according to EU guidelines.
This study received a Klimisch score of 1 and is classified as reliable without restriction because it was conducted similar to OECD guideline 403 and GLP.
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