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EC number: 700-397-7 | CAS number: 847488-62-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity:
rat (Sprague-Dawley) m/f; LD50 > 5000 mg/kg bw [EU Method B.1, GLP; test item: structural analogue with EC 413-750-2]
Acute inhalation toxicity:
- rat (Sprague-Dawley) m/f; LC50 > 7.5 mg/L air (4h) [OECD TG 403, GLP; test item: structural analogue with EC 413-750-2]
Acute dermal toxicity:
rat (Sprague-Dawley) m/f; LD50 > 2000 mg/kg bw (24h) [EU Method B.3; test item: structural analogue with EC 413-750-2]
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study obtained through inquiry process; SNIF file obtained from ECHA.
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Sex:
- male/female
- Route of administration:
- oral: unspecified
- Vehicle:
- other: Methylcellulose 400 cps water solution
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- - Male: 5
- Female: 5 - Control animals:
- not specified
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- not specified
- Mortality:
- - Male: 5000 mg/kg bw; Number of animals: 5; Number of deaths: 0
- Female: 5000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: Piloerection was observed only two hours after test article administration in two male and three female rats.
- Gross pathology:
- Effects on organs: At the gross pathology examination carried out at the end of the observation period no changes were noted in all necropsied
animals. - Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: EU-GHS
- Conclusions:
- LD50 (rat) > 5000 mg/kg bw
The test substance, when administered by oral route to rat, under the conditions adopted in this study, did not cause overt signs of toxicity. - Executive summary:
The acute oral toxicity of the structural analogue has been determined in a GLP test with rats according to EU method B.1 in a limit test. The LD50 value was > 5000 mg/kg bw, the test substance showed no toxicity under the conditions of the test.
Since EC 700-397-7 is a near analogue to the test substance (EC 413-750-2), the experimental data from this substance were used in a read-across approach.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- The data has been extracted from ECHA databases. The files were first migrated from the SNIF (Structured Notification Interchange Format) format (used under Directive 67/548/EEC) into the IUCLID 5 format (used under the REACH Regulation) and represent all of the information that ECHA currently holds on this endpoint, which were submitted in the framework of a notification at least 12 years previously (as per Article 25(3)) for the substance with the same EC number for which you inquired.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study obtained through inquiry process; SNIF file obtained from ECHA.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- other: no data
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Route of administration:
- inhalation
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- The nominal concentrations administered were 87.85 mg/L (group 1) and 70.14mg/L (group 2).
- No. of animals per sex per dose:
- - Male: 5
- Female: 5 - Control animals:
- not specified
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 7.5 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- - Male: 4.07 mg/L; Number of animals: 5; Number of deaths: 0
- Male: 7.53 mg/L; Number of animals: 5; Number of deaths: 0
- Female: 4.07 mg/L; Number of animals: 5; Number of deaths: 0
- Female: 7.53 mg/L; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: An unkempt appearance was noted for all Group 1 animals immediately post dose and one animal of Group 2 appeared subdued and showed hunched posture over the first 24h post dose. Otherwise no other abnormalities w
- Body weight:
- There was no effect on body weight profile following exposure to the test substance.
- Gross pathology:
- Necropsy examination:
All Group 1 animals were seen to have no abnormalities.
Slightly mottled lungs in all but 2 Group 2 animals and pale/discoloured lungs were noted in one Group 2 male and 1 Group 2 female. These were
deemed to be in accordance with normal background findings in acute rat studies at IRI and not attributable to treatment.
Body weight ratio:
Lung:body weight ratios were generally within normal limits for all animals, although Group 2 males tended towards the bottom of the expected
range. - Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: Eu GHS
- Conclusions:
- LC50 (rat) > 7.5 mg/L air (4h)
The test substance did not produce any evidence of toxicity in Sprague-Dawley rats following exposure for 4 h to an atmosphere containing 7.53 mg/L air (measured gravimetrically). - Executive summary:
The acute inhalation toxicity of the structural analogue has been determined in a GLP test with rats according to OECD Guideline No. 403. The test substance did not produce any evidence of toxicity in Sprague-Dawley rats following exposure for 4 h to an atmosphere containing 7.53 mg/L air (measured gravimetrically), so the LC50 value is > 7.5 mg/L air (4h).
Since EC 700-397-7 is a near analogue to the test substance (EC 413-750-2), the experimental data from this substance were used in a read-across approach.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- The data has been extracted from ECHA databases. The files were first migrated from the SNIF (Structured Notification Interchange Format) format (used under Directive 67/548/EEC) into the IUCLID 5 format (used under the REACH Regulation) and represent all of the information that ECHA currently holds on this endpoint, which were submitted in the framework of a notification at least 12 years previously (as per Article 25(3)) for the substance with the same EC number for which you inquired.
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study obtained through inquiry process; SNIF file obtained from ECHA.
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- other: no data
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Type of coverage:
- semiocclusive
- Vehicle:
- not specified
- Duration of exposure:
- 24
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- - Male: 5
- Female: 5 - Control animals:
- not specified
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- - Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
- Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: the rats did not show any clinical sign or change in behaviour.
- Gross pathology:
- Effects on organs: no changes were observed in the animals killed at the end of the study.
- Other findings:
- Signs of toxicity (local): no reaction was observed at the application site.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: EU GHS
- Conclusions:
- LD50 (rat) > 2000 mg/kg bw
The test substance, when administered by dermal route to rat, under the conditions adopted in this study, did not cause mortality nor toxic effects. - Executive summary:
The acute dermal toxicity of the structural analogue has been determined in a GLP test with rats according to EU methog B.3 in a limit test. The LD50 (24h) value was > 2000 mg/kg bw, the test substance did not cause mortality nor toxic effects under the conditions of the test.
Since EC 700-397-7 is a near analogue to the test substance (EC 413-750-2), the experimental data from this substance were used in a read-across approach.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- The data has been extracted from ECHA databases. The files were first migrated from the SNIF (Structured Notification Interchange Format) format (used under Directive 67/548/EEC) into the IUCLID 5 format (used under the REACH Regulation) and represent all of the information that ECHA currently holds on this endpoint, which were submitted in the framework of a notification at least 12 years previously (as per Article 25(3)) for the substance with the same EC number for which you inquired.
Additional information
Since EC 700-397-7 is a near analogue to the test substance (EC 413-750-2), the experimental data from this substance were used in a read-across approach:
Acute oral toxicity
The acute oral toxicity of the structural analogue has been determined in a GLP test with rats according to EU methog B.1 in a limit test. The LD50 value was > 5000 mg/kg bw, the test substance showed no toxicity under the conditions of the test.
Acute inhalation toxicity
The acute inhalation toxicity of the structural analogue has been determined in a GLP test with rats according to OECD Guideline No. 403. The test substance did not produce any evidence of toxicity in Sprague-Dawley rats following exposure for 4 h to an atmosphere containing 7.53 mg/L air (measured gravimetrically), so the LC50 value is > 7.5 mg/L air (4h).
Acute dermal toxicity
The acute dermal toxicity of the structural analogue has been determined in a GLP test with rats according to EU methog B.3 in a limit test. The LD50 (24h) value was > 2000 mg/kg bw, the test substance did not cause mortality nor toxic effects under the conditions of the test.
Justification for selection of acute toxicity – oral endpoint
GLP and guideline study
Justification for selection of acute toxicity – inhalation endpoint
GLP and guideline study
Justification for selection of acute toxicity – dermal endpoint
GLP and guideline study
Justification for classification or non-classification
Acute oral toxicity
The test material does not meet the criteria for classification and will not require labelling for oral toxicity in accordance with European Regulation (EC) No. 1272/2008.
Acute inhalation toxicity
The test material does not meet the criteria for classification and will not require labelling for inhalation toxicity in accordance with European Regulation (EC) No. 1272/2008.
Acute dermal toxicity
The test material does not meet the criteria for classification and will not require labelling for dermal toxicity in accordance with European Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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