Registration Dossier
Registration Dossier
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EC number: 233-139-2 | CAS number: 10043-35-3
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards with acceptable restrictions.
Data source
Reference
- Reference Type:
- publication
- Title:
- Prediction of an occupational exposure limit for a mixture on the basis of its components: Application to metalworking fluids.
- Author:
- Krystofiak SP & Schaper MM
- Year:
- 1 996
- Bibliographic source:
- American Industrial Hygiene Association Journal 57: 239 - 244
Materials and methods
- Type of study / information:
- Using a mouse bioassay a synthetic metalworking fluid and its major components, including boric acid, were evaluated for sensory and pulmonary irritation. Using respiratory frequency, depression, concentration-response relationships were developed. From such relationships the concentration capable of evoking a 50 % decrease in mean frequency was determined.
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Using a mouse bioassay a synthetic metalworking fluid and its major components, including boric acid, were evaluated for sensory and pulmonary irritation. Using respiratory frequency, depression, concentration-response relationships were developed. From such relationships the concentration capable of evoking a 50 % decrease in mean frequency was determined.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Boric acid
- EC Number:
- 233-139-2
- EC Name:
- Boric acid
- Cas Number:
- 10043-35-3
- Molecular formula:
- H3BO3
- IUPAC Name:
- boric acid
Constituent 1
Results and discussion
Any other information on results incl. tables
Mild sensory irritation occurred after 30 min of exposure and continued throughout the exposure. No pulmonary irritation occurred during the exposure.
Applicant's summary and conclusion
- Conclusions:
- Mild sensory irritation occurred after 30 min of exposure to boric acid and continued throughout the exposure. No pulmonary irritation occurred during the exposure.
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