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EC number: 257-098-5 | CAS number: 51274-00-1 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 77492.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: as reported in source record(s)
- Remarks:
- This target record summarises individual studies on the toxicity to aquatic algae and cyanobacteria that ranged in reliability from 2-3.
- Justification for type of information:
- see "Endpoint-specific read-across justification for nanoforms of iron oxide_2021” and "Read-across justification-environ assessment-iron oxides_2021” attached in IUCLID section 13
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across: supporting information
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 20 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: as reported in source record
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 20 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: as reported in source record
Reference
Description of key information
Applying read-across (category approach) to diiron trioxide in nanoform (see attachment "Iron oxides category justification” in IUCLID section 13), iron hydroxide oxide yellow in nano-form (alpha) is considered not toxic to aquatic algae. In a reliable 72 h algae growth inhibition test according to OECD 201 with Fe2O3 nanoparticles, no significant effect on the growth rate of Pseudokirchneriella subcapitata was observed at the applied concentrations of 8.2 to 20.0 mg/L and thus an unbounded 72 h NOEC≥20 mg/L (nominal) was derived.
Key value for chemical safety assessment
Additional information
In a supporting, non-guideline study, effects of diiron trioxide nanoparticles (α-Fe2O3-NP) on the freshwater algae Chlorella pyrenoidosa were assessed (Lei et al., 2016). Based on the obtained results a 96 h IC50 and IC10 forα-Fe2O3 of 71.0 and ~20 mg/L (graphical estimate, extrapolated value) were assessed, respectively. The study is considered as supporting only since it cannot be considered reliable due to a number of methodological shortcomings. It is not clear whether growth rates were calculated from cell counts (only % inhibition is presented) and the growth of the control cannot be checked (validity criteria not assessable).
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