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Diss Factsheets
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EC number: 208-915-9 | CAS number: 546-93-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Magnesium carbonate is not considered to be acutely harmful by the oral route. Testing via the dermal and inhalation routes is not required or scientifically justified.
Key value for chemical safety assessment
Additional information
Acute toxicity - Oral route:
The oral LD50 for magnesium carbonate when administered to rats was >2000 mg/kg bw.
Magnesium is also essential for life and occurs in the natural environment. Humans are widely exposed to naturally occurring magnesium carbonate and chloride, e.g. via drinking water and food on a day to day basis. Ingested magnesium, carbonate and chloride ions are actively regulated by the body and are therefore not considered to be systemically toxic in standard test systems.
Acute toxicity - Dermal route: Dermal toxicity to magnesium carbonate is considered to be unlikely due to the inorganic nature of the substance limiting absorption through the skin and the lack of systemic toxicity seen in the acute oral toxicity study.
Furthermore, magnesium carbonate is an approved ingredient of cosmetics for topical application to skin.
Acute toxicity - Inhalation route: Magnesium carbonate is always prepared and used as a suspension. Therefore, inhalation of magnesium carbonate is not considered to be a likely route of exposure.
Justification for classification or non-classification
Oral: The oral LD50 for rats was > 2000 mg/kg bw in an OECD Guideline 420 study. Therefore the substance does not require classification according to the criteria described in Regulation (EC) No 1272/2008.
Dermal: Dermal toxicity to magnesium carbonate is considered to be unlikely due to the inorganic nature of the substance limiting absorption through the skin and the lack of systemic toxicity seen in the acute oral toxicity study. Therefore, magnesium carbonate does not require classification according to the criteria described in Regulation (EC) No 1272/2008.
Inhalation: Inhalation of magnesium carbonate is not considered to be a likely route of exposure. Therefore, magnesium carbonate does not require classification according to the criteria described in Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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