Registration Dossier
Registration Dossier
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EC number: 209-529-3 | CAS number: 584-08-7
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: excerpts from peer-reviewed international assessment reports
Data source
Referenceopen allclose all
- Reference Type:
- other: international assessment report
- Title:
- SIDS Initial Assessment Report for 13th SIAM (Bern, 6-9 November 2001) Potassium chloride
- Author:
- OECD
- Year:
- 2 001
- Bibliographic source:
- UNEP (United nations Environment Program) PUBLICATIONS, published via Internet: http://www.inchem.org/documents/sids/sids/KCHLORIDE.pdf
- Reference Type:
- other: international assessment report
- Title:
- SIDS Initial Assessment Report for SIAM 22 (Paris, France 18-21 April 2006) Bicarbonate special
- Author:
- OECD
- Year:
- 2 006
- Bibliographic source:
- OECD (Organisation for Economic Co-operation and Development) Environmental Directorate , published via Internet: http://www.oecd.org/document/63/0,3343,en_2649_34379_1897983_1_1_1_1,00.html
Materials and methods
- Principles of method if other than guideline:
- synopsis on toxicokinetics of potassium and carbonate
Test material
- Reference substance name:
- Potassium chloride
- EC Number:
- 231-211-8
- EC Name:
- Potassium chloride
- Cas Number:
- 7447-40-7
- Molecular formula:
- ClK
- IUPAC Name:
- potassium chloride
- Reference substance name:
- Sodium hydrogencarbonate
- EC Number:
- 205-633-8
- EC Name:
- Sodium hydrogencarbonate
- Cas Number:
- 144-55-8
- Molecular formula:
- CH2O3.Na
- IUPAC Name:
- sodium hydrogen carbonate
- Reference substance name:
- Sodium carbonate
- EC Number:
- 207-838-8
- EC Name:
- Sodium carbonate
- Cas Number:
- 497-19-8
- Molecular formula:
- CH2O3.2Na
- IUPAC Name:
- disodium carbonate
- Reference substance name:
- Ammonium hydrogencarbonate
- EC Number:
- 213-911-5
- EC Name:
- Ammonium hydrogencarbonate
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: no bioaccumulation potential based on study results
In conclusion, the ions K+ or (CO3)2- resulting from the ionisation (dissociation) of K2CO3 will not influence the natural K+ or (CO3)2- level in the body due to natural regulation mechanisms. - Executive summary:
After ingestion, potassium carbonate rapidly dissociates in the gastric juice to yield carbonate ions (CO32-) and potassium ions (K+), at this stage, the alkalinity is neutralized by the stomach acid. For this reason undissociated potassium carbonate is not expected to be systemically available in the body under normal handling and use conditions.
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