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EC number: 932-349-8 | CAS number: 8006-64-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
- Endpoint:
- long-term toxicity to fish, other
- Remarks:
- Calculation method
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- From 2019-03-06 to 2019-03-07
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- Not applicable.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 210 (Fish, Early-Life Stage Toxicity Test)
- Deviations:
- yes
- Remarks:
- QSAR model
- Principles of method if other than guideline:
- The chronic toxicity to fish was determined using a validated QSAR for the Mechanism of Action (MechoA) in question (MechoA 1.1, i.e. non-polar narcosis) (Bauer et al., 2018). The QSAR is based on validated data for a training set of 27 chemicals derived from 32-day test on fish, for which the concentrations of the test item had been determined by chemical analyses over the test period.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,6,6-trimethylbicyclo[3.1.1]hept-2-ene; 3,7,7-trimethylbicyclo[4.1.0]hept-3-ene; 3-methylidene-6-(propan-2-yl)cyclohex-1-ene; 6,6-dimethyl-2-methylidenebicyclo[3.1.1]heptane; 7-methyl-3-methylideneocta-1,6-diene
- EC Number:
- 932-349-8
- Cas Number:
- 8006-64-2
- Molecular formula:
- C10H16
- IUPAC Name:
- 2,6,6-trimethylbicyclo[3.1.1]hept-2-ene; 3,7,7-trimethylbicyclo[4.1.0]hept-3-ene; 3-methylidene-6-(propan-2-yl)cyclohex-1-ene; 6,6-dimethyl-2-methylidenebicyclo[3.1.1]heptane; 7-methyl-3-methylideneocta-1,6-diene
- Test material form:
- liquid
- Details on test material:
- Name of test material (as cited in study report): Turpentine ; turpentine oil
Constituent 1
- Specific details on test material used for the study:
- None.
Sampling and analysis
- Analytical monitoring:
- not required
- Details on sampling:
- Not applicable.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Not applicable.
Test organisms
- Test organisms (species):
- not specified
- Details on test organisms:
- None.
Study design
- Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 32 d
- Remarks on exposure duration:
- None.
- Post exposure observation period:
- None.
Test conditions
- Hardness:
- Not applicable.
- Test temperature:
- Not applicable.
- pH:
- Not applicable.
- Dissolved oxygen:
- Not applicable.
- Salinity:
- Not applicable.
- Conductivity:
- Not applicable.
- Nominal and measured concentrations:
- Estimated value.
- Details on test conditions:
- None.
- Reference substance (positive control):
- not required
Results and discussion
Effect concentrations
- Duration:
- 32 d
- Dose descriptor:
- EL10
- Effect conc.:
- 0.43 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- other: egg/sac fry, growth inhibition of juvenile fish, early life stage, full life cycle
- Remarks on result:
- other: result based on the typical composition
- Details on results:
- Not applicable.
- Results with reference substance (positive control):
- Not applicable.
- Reported statistics and error estimates:
- Not applicable.
Any other information on results incl. tables
Analytically Measured Aqueous Phase (AMAP) calculated at the predicted EL10.
constituents | concentration in the WAF (mg.L-1) |
Constituent 1 | 0.32 |
Constituent 2 | 0.07 |
Constituent 3 | 0.0051 |
Constituent 4 | 0.0034 |
Constituent 5 | 0.003 |
Constituent 6 | 0.0021 |
Constituent 7 | 0.0017 |
Constituent 8 | 0.00043 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The chronic toxicity to fish of the test item has been determined using the calculation method for mixtures based on WAF studies. The test item constituents which have been considered fall individually within the applicability domain of the model used to determine the chronic toxicity to fish (as the 32d-EC10). Therefore, the final result for the test item can be considered valid for use in risk assessment and classification and labelling.
The 32d-EL10 of the test item to fish was predicted as 0.43 mg/L. - Executive summary:
A calculation method prediction was performed to assess the chronic toxicity to fish of the test item, GUM TURPENTINE OIL using the WAF method. This calculation method predicts the endpoint value which would be expected when testing the substance under experimental conditions in a laboratory following the Guideline for Testing of Chemicals No. 210, "Fish, Early-life Stage Toxicity Test" (OECD, 2013). The criterion predicted was the EL10 (10% Effective Loading rate), a loading rate which is expected to cause an effect of 10% on growth within a period of 32 days. The chronic toxicity to fish was determined using a calculation method for the Mechanism of Action (MechoA) in question (MechoA 1.1, i.e. non-polar narcosis) (Bauer et al., 2018). This method has previously been validated in an internal publication for acute exposure of non-polar narcosis compounds (Bicherel and Thomas, 2014). The algorithm is based on a QSAR model which has been validated to be compliant with the OECD recommandations for QSAR modeling (OECD, 2004, 2007). The QSAR model is based on validated data for a training set of 27 chemicals derived from 32-day test on fish, for which the concentrations of the test item had been determined by chemical analyses over the test period. Further to this the effective loading rate of the WAF is determined by using a series of calculation steps using phase equilibrium thermodynamics and excluding the non-bioavailable fraction, this approach is based on validated data derived from 32-day EL10 tests on fish, for which the concentrations of the test item had been determined by chemical analyses over the test period.
The result below is the chronic toxicity value anticipated during a 32-day EL10study on fish based on the WAF method. The 32-day EL10is calculated as follows:
Composition
Time (d)
EL10(mg test item.L-1)
typical
32
0.43
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