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EC number: 260-633-5 | CAS number: 57219-64-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Non GLP study. The study was conducted according to a method equivalent to the OECD 401 guideline without major deviations. However, no data on test conditions are reported. Follow-up of body weight was done weekly, however no individual animal data were reported.
Data source
Reference
- Reference Type:
- publication
- Title:
- The acute, chronic and topical toxicity of zirconium carbonate.
- Author:
- Harrisson JWE, Trabin B, Martin EW
- Year:
- 1 951
- Bibliographic source:
- J Pharmacol Exp Ther Jul; 102(3): 179-84
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- [μ-[carbonato(2-)-O:O']]dihydroxydioxodizirconium
- EC Number:
- 260-633-5
- EC Name:
- [μ-[carbonato(2-)-O:O']]dihydroxydioxodizirconium
- Cas Number:
- 57219-64-4
- Molecular formula:
- CH2O7Zr2
- IUPAC Name:
- [({[Hydroxy(Oxo)Zirconio]Oxy}Carbonyl)Oxy]Zirconiumoylol
- Details on test material:
- - Name of test material (as cited in study report): hydrated zirconium carbonate
- Molecular formula (if other than submission substance): 3ZrO2.CO2.H2O
- Molecular weight (if other than submission substance): no data
- Smiles notation (if other than submission substance): no data
- InChl (if other than submission substance): no data
- Structural formula attached as image file (if other than submission substance): no data
- Substance type: no data
- Physical state: water insoluble moist paste
- Analytical purity: no data
- Impurities (identity and concentrations): no data
- Composition of test material, percentage of components: 3ZrO2.CO2.H2O equivalent to 20.9 % ZrO2
- Isomers composition: not applicable
- Purity test date: no data
- Lot/batch No.: no data
- Expiration date of the lot/batch: no data
- Radiochemical purity (if radiolabelling): not applicable
- Specific activity (if radiolabelling): not applicable
- Locations of the label (if radiolabelling): not applicable
- Expiration date of radiochemical substance (if radiolabelling): not applicable
- Stability under test conditions: not applicable
- Storage condition of test material: not applicable
- Other: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: 7 to 8 months old
- Weight at study initiation: 350 g (preliminary test), 180 g (second more extensive test)
- Fasting period before study: 24 hours
- Housing: all rats were housed individually
- Diet (e.g. ad libitum): normal diet
- Water (e.g. ad libitum): no data
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: no data
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- not specified
- Details on oral exposure:
- Each rat was individually supplied once with a mixture of cheese and hydrated zirconium carbonate (HZC), calculated to provide single doses equivalent to 2,4, 8 or 10 gZrO2/kg bw (respectively 9.6, 19.1, 38.3, 47.85 g/kg bw of HZC)
- Doses:
- 2, 4, 8 or 10 gZrO2/kg bw (respectively 9.6, 19.1, 38.3, 47.85 g/kg bw of HZC)
- No. of animals per sex per dose:
- five adult rats were used per dose (preliminary study)
50 young adult male rats were used in a second more extensive acute test - Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: all rats were observed for 60 days, during wich period they received a normal diet
- Frequency of observations and weighing: Their general condition was noted daily and they were weighed weekly, as a check against delayed effects
- Necropsy of survivors performed: yes
- Other examinations performed: gross necropsy - Statistics:
- No data
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 47 850 other: mg /kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occurred during either the preliminary test with the group of 20 adult male rats or the more extensive test with 50 younger adult male rats.
- Clinical signs:
- other: All animals continued to grow at a normal rate. No significant differences were noted among the test groups and the controls indicating that the acute oral toxicity of the zirconium carbonate was very low.
- Gross pathology:
- Gross examination of the autopsied animals revealed nothing abnormal.
- Other findings:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- No deaths occured during either the preliminary test with the group of 20 adult male rats or the more extensive test with 50 younger adult male rats. All animals continued to grow at a normal rate and gross examination of the autopsied animals revealed nothing abnormal up to a dose of 47850 mg/kg bw (based on test material).
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