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EC number: 243-957-1 | CAS number: 20667-12-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989-02-21 to 1989-02-24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Guideline study. At the time of the study conduct, GLP was not compulsory. However, the study was conducted in accordance with the principles of GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Disilver oxide
- EC Number:
- 243-957-1
- EC Name:
- Disilver oxide
- Cas Number:
- 20667-12-3
- Molecular formula:
- Ag2O
- IUPAC Name:
- silver(1+) oxide
- Details on test material:
- - Name of test material (as cited in study report): silver(I)-oxide
- Physical state: brown-grey powder
- Stability under test conditions: Not indicated by the sponsor.
- Storage condition of test material: st room temperature
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: white russian (albino)
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: ASTA Pharma AG, Bielefeld
- Age at study initiation: 9 months (males) and 11 months (females)
- Weight at study initiation: 2.6 kg (males); 2.7 and 3.2 kg (females)
- Housing: stainless steel cages with grating floor, type ASTA, size: 48.5x40x36.5 cm (LxBxH), individually housing
- Diet: approx. 120 g/day x animal (Standard diet, ssniff K, "Special Diet for Rabbits" supplied by ssniff Spezialfutter GmbH, D-4770 Soest)
- Water: ad libitum
- Acclimation period: 1 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 22
- Humidity (%): 45 - 60
- Photoperiod: 12 hours dark/light
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- other: The opposite area of the treated dorsal skin was used as control site (no test material application).
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g of the test substance were moistened with demineralised water and placed on the shorn dorsal skin.
VEHICLE
- Amount(s) applied (volume or weight with unit): 0.35 mL - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1, 24, 48 and 72 hours after removal of the patches
- Number of animals:
- 3 rabbits (1 male and 2 females)
- Details on study design:
- TEST SITE
- Area of exposure: The test material was placed on the shorn dorsal skin area between shoulder and sacrum.
- Type of wrap if used: The site of application was covered with a linen cloth (approx. 6.25 cm2) which adhered to a synthetic film glue. A bandage wrapped several times around the trunk (Acrylastic, No. 2408, width 8 cm; P. Beiersdorf and Co. AG, Hamburg) provided a complete occlusion.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): After the end of the exposition time remaining test material was gently washed off as far as possible.
SCORING SYSTEM: The treated skin area was qualitatively (erythema/ eschar resp. edema) and quantitatively (values 0-4) assessed using the DRAIZE method. In addition, attention was paid to the occurrence of further reactions on the skin (e.g. corrosive effect) and to clinical symptoms (systemic toxic effects).
EVALUATION: The evaluation of the cutaneous irritation effect at observation times 1, 24, 48 and 72 hours p. appl. was expressed by an irritation index. A corresponding gradation was allocated to this index by the following scheme in a modified method according to Gilman et al. (1983):
0 - 0.5 = non irritant
0.6 - 3.0 = slightly irritant
3.1 - 5.0 = moderately irritant
5.1 - 8.0 = severly irritant
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Irritant / corrosive response data:
- The single application of 0.5 gram silver(I)-oxide to the intact skins of 3 rabbits caused no changes. During the observation period neither erythema nor edema could be detected.
- Other effects:
- The treated skin area was yellow to brown discoloured 24 hours after removal of the patch until the end of the 14-day observation period.
Systemic-toxic effects did not occur after dermal application of the test substance. The general condition of the test animals was not affected.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Silver(I)-oxide is not irritant to the skin
- Conclusions:
- The irritation index is 0.0.
Silver(I)-oxide therefore is a non-irritant in this test system.
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