Registration Dossier
Registration Dossier
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EC number: 292-122-8 | CAS number: 90552-02-6
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The absence of a mutagenic potential was demonstrated for gene mutations as well as chromosome mutations for isodecyl methacrylate.
These results are representative for all long chain methacrylate esters as isodecyl methacrylate represents a worst-case in terms of bioavailability due to its molecular size, lipophilicity and water solubility.
Two in mouse micronucleus tests with C12 and C18 methacrylate ester demonstrate the absence of a mutagenic potential in vivo.
Short description of key information:
The absence of a mutagenic potential was demonstrated for gene mutations as well as chromosome mutations for isodecyl methacrylate. These results are representative for all long chain methacrylate esters as isodecyl methacrylate represents a worst-case in terms of bioavailability due to its molecular size, lipophilicity and water solubility.
Two in mouse micronucleus tests with C12 and C18 methacrylate ester demonstrate the absence of a mutagenic potential in vivo.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
EU classification according to Annex VI of the Directive 67/548/EEC:
- No classification required.
GHS classification according to Annex I 1272/2008 CLP (EU GHS):
- No classification required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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