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Diss Factsheets
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EC number: 264-150-0 | CAS number: 63449-39-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water and sediment: simulation tests
Administrative data
- Endpoint:
- biodegradation in water: sediment simulation testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Considered adequate for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Accumulation and depuration of sediment-sorbed C12- and C16-polychlorinated alkanes by oligochaetes (Lumbriculus variegatus)
- Author:
- Fisk AT, Wiens SC, Webster GRB, Bergman A and Muir DCG
- Year:
- 1 998
- Bibliographic source:
- Envir. Toxicol. Chem 17: 2019-2026.
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 005
Materials and methods
- Principles of method if other than guideline:
- The half lives of two C16 chlorinated paraffins (representing the extremes of the typical chlorine contents in commercial production) were determined in sediment (containing oligochaetes)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Medium-Chain Chlorinated Paraffin (MCCP)
- IUPAC Name:
- Medium-Chain Chlorinated Paraffin (MCCP)
- Reference substance name:
- 85525-85-9
- IUPAC Name:
- 85525-85-9
- Details on test material:
- - Name of test material (as cited in study report): 14C-labelled C16H31Cl3 and C16H21Cl13
- Substance type: technical products
- Physical state: liquid
- Analytical purity: no data
- Impurities (identity and concentrations): no details on presence or absence of a stabiliser
- Composition of test material, percentage of components: C16 chlorinated paraffins, with 35 and 69% chlorination.
- Radiochemical purity (if radiolabelling): no data
- Specific activity (if radiolabelling): 22.7 and 25 mCi/mmol for the 35 and 69% chlorinated paraffins
- Locations of the label (if radiolabelling): Carbon 1 for the 35% chlorinated paraffin and uniformerly labelled for the 69% chlorinated paraffin
- Expiration date of radiochemical substance (if radiolabelling): no data
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
not relevant - Radiolabelling:
- yes
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- natural water / sediment
- Details on source and properties of surface water:
- - Details on collection (e.g. location, sampling depth, contamination history, procedure): Ekman dredge from Lake 468, an oligotrophic, uncontaminated lake at the Experimental Lakes Area (ELA), Ontario, Canada in October 1995
- Storage conditions: Stored at 4oC - Details on source and properties of sediment:
- - Details on collection (e.g. location, sampling depth, contamination history, procedure): Ekman dredge from Lake 468, an oligotrophic, uncontaminated lake at the Experimental Lakes Area (ELA), Ontario, Canada in October 1995
- Storage conditions: Stored at 4oC under 1 cm of lake water
- Textural classification (i.e. %sand/silt/clay): 76/21/3
- Organic carbon (%):1.3-1.5 dry wt
- Sediment samples sieved: yes - Details on inoculum:
- no data
- Duration of test (contact time):
- ca. 14 d
Initial test substance concentrationopen allclose all
- Initial conc.:
- ca. 47.1 other: ng/g (dry weight; C16 chlorinated paraffin; 35% Cl)
- Based on:
- test mat.
- Initial conc.:
- ca. 135 other: ng/g (dry weight; C16 chlorinated paraffin; 69% Cl)
- Based on:
- test mat.
- Initial conc.:
- ca. 264 other: ng/g (dry weight; C16 chlorinated parrafin; 69% Cl)
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- radiochem. meas.
- Details on study design:
- no data
Reference substance
- Reference substance:
- other: dichlorinated alkanes
Results and discussion
- Test performance:
- no data
Half-life of parent compound / 50% disappearance time (DT50)open allclose all
- Compartment:
- sediment
- DT50:
- ca. 12 d
- St. dev.:
- 1
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: C16 chlorinated paraffin; 35% Cl
- Compartment:
- sediment
- DT50:
- ca. 58 d
- St. dev.:
- 58
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: C16 chlorinated paraffin; 69% Cl
- Transformation products:
- not measured
- Details on transformation products:
- no data
- Evaporation of parent compound:
- not specified
- Volatile metabolites:
- not specified
- Residues:
- not specified
- Details on results:
- The r2 value for the degradation rates were greater than 0.93 for the 35 % chlorinated paraffin and 0.49 for the 69% chlorinated paraffin
- Results with reference substance:
- no data
Applicant's summary and conclusion
- Conclusions:
- In an aerobic sediment system containing oligochaetes (Lumbriculus variegatus), the half-lives of two 14C-labelled C16 chlorinated paraffins were estimated to be about 12 and 58 days for the 35% and 69% chlorinated paraffin, respectively.
- Executive summary:
The half-lives of two 14C-labelled C16 chlorinated paraffins were estimated to be about 12 days and 58 days for the 35 and 69% chlorinated paraffin, respectively, in an aerobic sediment system (freshwater) containing oligochaetes (Lumbriculus variegatus). The extent of degradation was determined at day 0 and day 14 of the experiments based on the difference between toluene-extractable 14C measurements (taken to represent unchanged chlorinated paraffin) and total 14C measurements. The r2 value for the degradation rates were greater than 0.93 for the 35% chlorinated paraffin and 0.49 for the 69% chlorinated paraffin.
The RAR (EU, 2005) notes that the "results of this test should be treated with caution as the identity of the 14C present in the samples was not determined, and it was only assumed that the non-extractable 14C represented metabolites".
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