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Diss Factsheets
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EC number: 212-485-8 | CAS number: 822-06-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Persistence Assessment
Hexamethylene disiocyanate (HDI) is not readily biodegradable with 42 % biodegradation in 28 days (Bayer AG, 2000). However, biodegradation is irrelevant as primary degradation step because of immediate hydrolysis takes place with a half-life of 0.23 hours. The hydrolysis products are mainly polyurea components and to a very low extent hexamethylene diamine. Polyurea is known to be inert and is probably due to its molecular size not bioavailable. Moreover, polyurea is considered insoluble in water and is characterised by limited mobility. However, a full weight-of-evidence approach as described in REACH Guidance Document R11 (2017) is not possible due to the limitations of the available hydrolysis studies. Therefore, based on the results of the ready and inherent biodegradation studies, HDI is classified as preliminary persistent according to screening criteria.
Bioaccumulation Assessment
Measured bioconcentration factors (BCF) for hexamethylene diisocyanate (HDI) are not available. Hexamethylene diisocyanate (HDI) hydrolyses rapidly in the presence of water with a half life of 0.23 hours. Therefore a risk estimation regarding the bioaccumulation potential of hexamethylene diisocyanate (HDI) on the basis of a log Kow, determined by QSAR, is misleading. A calculated theoretical log Kow value of 3.2 reflects the unreacted molecule without influence of water.
The hydrolysis product, hexamethylene diamine (HDA) is also not bioaccumulative. With a measured log Kow (OECD 107) of 0.02 (BASF 1978, not validated), a BCF of 3.2 was calculated with BCFWIN Program (v2.17)) (Currenta 2009f).
On the basis of these information it can not be expected that bioaccumulation of hexamethylene diisocyanate (HDI) occurs. Therefore the B and the vB criteria are not fulfilled.
T-criterion
There is one aquatic toxicity test for algae available which counts as a chronic test. The NOEC was 11.7 mg/l. Furthermore, the substance is not classified as carcinogenic, mutagenic or toxic for reproduction according to criteria of REACH Annex XIII. For these reasons, the substance does not meet the T-criterion.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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