Registration Dossier
Registration Dossier
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EC number: 200-909-4 | CAS number: 75-86-5
Carcinogenicity
Administrative data
Description of key information
No studies regarding the carcinogenic potential of 2-hydroxy-2-methylpropionitril were located in the available literature.
Under physiological conditions, 2-hydroxy-2-methylpropionitrile decomposes to yield its molar equivalent in hydrogen cyanide (HCN) and acetone.
Carcinogenicity studies performed on HCN and acetone gave no evidence on intrinsic carcinogenic activity of these degradation products at all.
Genetic toxicity studies with 2-hydroxy-2-methylpropionitril were generally negative, as well as genetic toxicity studies performed with HCN, HCN salts and acetone (see chapter 7.6).
In conclusion, there is no indication on intrinsic carcinogenic activity of 2 -hydroxy-2 -methylpropionitril.
Key value for chemical safety assessment
Justification for classification or non-classification
There is no evidence on intrinsic carcinogenic activity of 2-hydroxy-2-methylpropionitrile. Thus 2-hydroxy-2-methylpropionitrile does not comply with the classification requirements regarding carcinogenicity outlined in regulation (EC) 1272/2008 or the former directive on classification and labelling 67/548/EWG.
Additional information
No studies regarding the carcinogenic potential of 2-hydroxy-2-methylpropionitril were located in the available literature.
Under physiological conditions, 2-hydroxy-2-methylpropionitrile decomposes to yield its molar equivalent in hydrogen cyanide (HCN) and acetone. Carcinogenicity studies performed on hydrogen cyanide and acetone gave no evidence on intrinsic carcinogenic activity of these degradation products at all: "No cancers were induced in rats in a two-year feeding study with HCN" (quotation taken from rationale for AEGL (Acute Exposure Guideline Levels) established by the AEGL-COMMITTEE (US-NAC, Acetone Cyanohydrin, Interim Acute Exposure Guideline Levels (AEGLs), Interim final draft, 2005). "Lifetime dermal carcinogenicity studies in mice treated with up to 0.2 mL of acetone did not reveal any increase in organ tumor incidence relative to untreated control animals" (quotation taken from SIDS Initial Assessment Report on Acetone, OECD UNEP Publications, 1999).
Genetic toxicity studies with 2-hydroxy-2-methylpropionitril were generally negative, as well as genetic toxicity studies performed with HCN, HCN alkali salts and acetone (see chapter 7.6).
In conclusion, there is no indication on intrinsic carcinogenic properties of 2 -hydroxy-2 -methylpropionitril.
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