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EC number: 405-740-1 | CAS number: 47073-92-7 AROCY L-10
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The acute oral LD50 was performed following OECD 401 using Sprague-Dawley rats; however only two dose levels were used. The LD50 was not closely defined. However, in another oral study (a sighting study for test 4.2.1) more than 50% of rats died within one day of receiving a dose of 1000 mg/kg. Thus the LD50 is 500-1000 mg/kg.
The inhalative LC50 study was performed following a modified Annex V limit test. A limit concentration of 2.6 mg/l was used because the results of the acute oral test suggested to the test laboratory that all animals would die if exposed to 5 mg/l. The marked weight loss and severe respiratory effects noted at 2.6 mg/l supported this prediction. Sprague-Dawley rats were used in this test, test item was applied as liquid aerosol to snout only. No mortality was noted besides of the clinical signs mentioned above. Gross pathology showed pale discoloration of the lungs in 4 out of ten animals.
The LD50 was performed similar or equal to OECD 402 using rabbits; one dose level was tested and four animals used. The acute dermal LD50 was found to be > 5000 mg/kg.
Based on these findings, the substance is classified as Harmful / Acute Tox. IV.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: test data from ELINCS-notification obtained from ECHA on 10-June-2010 (EC-no. 405-740-1 / notification-no. 91-06-0255-00); performed under GLP and according to EU-testing methods
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- ; only two dose levels
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- Dose levels of 500 and 5000 mg/kg were tested.
- No. of animals per sex per dose:
- 5 animals per sex and dose group.
- Control animals:
- no
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Males:
- 500 mglkg bw; Number of animals: 5; Number of deaths: 1
- 5000 mglkg bw; Number of animals: 5; Number of deaths: 5
Females:
- 500 mglkg bw; Number of animals: 5; Number of deaths: 0
- 5000 mglkg bw; Number of animals: 5; Number of deaths: 5 - Clinical signs:
- other: Signs of toxicity related to dose levels: - Deaths occured in all animals at 5000 mg/kg and one male at 500 mg/kg; all were within one day of dosing. - Prior to deaths sedation was noted, other less frequent signs included convulsions. - One survivor at 5
- Gross pathology:
- Effects on organs:
- No treatment-related macroscopic findings were reported. - Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The combined acute oral LD50 on rats was determined to be 500-1000 mg/kg.
- Executive summary:
The LD50 was performed following OECD 401 using Sprague-Dawley rats; however only two dose levels were used. The LD50 was not closely defined. However, in a dose-range finding study performed for a repeated dose toxicity test, more than 50% of rats died within one day of receiving a dose of 1000 mg/kg. Thus the LD50 is 500-1000 mg/kg and the substance is classified as Harmful / Acute Tox. IV.
Reference
In this study, with only two dose levels, the LD50 was not closely defined. However, in a dose-range finding study performed for a repeated dose toxicity test, more than 50% of rats died within one day of receiving a dose of 1000 mg/kg. Thus the LD50 is 500-1000 mg/kg.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 500 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: test data from ELINCS-notification obtained from ECHA on 10-June-2010 (EC-no. 405-740-1 / notification-no. 91-06-0255-00); performed under GLP and according to EU-testing methods
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- A limit concentration of 2.6 mg/l was used because the results of the acute oral test suggested to the test laboratory that all animals would die if exposed to 5 mg/l.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- other: snout only
- Vehicle:
- air
- Details on inhalation exposure:
- Mass median aerodynamic diameter (for liq.+solid aerosol):
Mass mean aerodynamic diameter 6.2 mcrometers; 25.5% of droplets were less than 3.5 micrometers in diameter - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- A limit concentration of 2.6 mg/l was used because the results of the acute oral test suggested to the test laboratory that all animals would die if exposed to 5 mg/l.
- No. of animals per sex per dose:
- 5 animals per sex and dose group.
- Control animals:
- no
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 2.6 mg/L air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- Males: 2.6 mg/L; number of animals: 5; Number of deaths: 0
Females: 2.6 mg/L; number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: In all animals there was no response to audio/physical stimuli on day 1, and abnormal respiration (very severe up to day 3), subdued behaviour and umkempt appearance until day 8-11. The severe respiratory effects noted post exposure included gasping, crac
- Body weight:
- Weight loss (by up to 30%) occurred in all animals during day 1 to 4.
- Gross pathology:
- Pale colouration of lungs was reported in 4/10 animals.
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Tle combined acute inhalative LC50 on rats was determined to be > 2.6 mg/L air.
- Executive summary:
This LC50 study was performed following a modified Annex V limit test. A limit concentration of 2.6 mg/l was used because the results of the acute oral test suggested to the test laboratory that all animals would die if exposed to 5 mg/l. The marked weight loss and severe respiratory effects noted at 2.6 mg/l supported this prediction. Sprague-Dawley rats were used in this test, test item was applied as liquid aerosol to snout only. No mortaslity was noted besides of the clinical signs mentioned above. Gross pathology showed pale discoloration of the lungs in 4 out of ten animals.
Based on these findings, the substance is classified as Harmful / Acute Tox. IV.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 2 600 mg/m³ air
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- August-December 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: no guideline study; not GLP-compliant
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Principles of method if other than guideline:
- four animals used
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- no data
- Duration of exposure:
- 24 hours
- Doses:
- Dose level: 5000 mg/kg
Dose volume: 4.1 ml/kg - No. of animals per sex per dose:
- 4 animals
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality observed
- Clinical signs:
- other: No clinical signs noted
- Gross pathology:
- No pathological findings noted
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal LD50 on rabbits was found to be > 5000 mg/kg.
- Executive summary:
The LD50 was performed similar or equal to OECD 402 using rabbits; one dose level was tested and four animals used. The acute dermal LD50 was found to be > 5000 mg/kg.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Additional information
Reliable data from ELINCS-notification (Klimisch 1)
Justification for selection of acute toxicity – inhalation endpoint
Reliable data from ELINCS-notification (Klimisch 1)
Justification for selection of acute toxicity – dermal endpoint
Reliable data from ELINCS-notification (Klimisch 2)
Justification for classification or non-classification
Based on the data available the substance needs to be classified and labelled as follows:
Regulation (EC) No 1272/2008
Signal word: Danger
Acute toxicity; Category 4 ; Oral
H302 Harmful if swallowed
Acute toxicity; Category 4 ; Inhalation
H332 Harmful if inhaled
Directive 67/548/EEC / 1999/45/EC
Xn, harmful
R20/22 - Harmful by inhalation and if swallowed
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