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Diss Factsheets
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EC number: 240-245-2 | CAS number: 16090-02-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Test procedures cannot be subsumed under a testing guideline. The test method is scientifically acceptable, nevertheless the report is not well documented and no many details are included.
Data source
Reference
- Reference Type:
- publication
- Title:
- Fluorescent Whitening Agents. Tests for skin-sensitizing potential.
- Author:
- Griffith J.F.
- Year:
- 1 973
- Bibliographic source:
- Arch. Dermatol. 107, 728-733
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
- Principles of method if other than guideline:
- Human repeated insult patch test.
- GLP compliance:
- no
Test material
- Reference substance name:
- Disodium 4,4'-bis[(4-anilino-6-morpholino-1,3,5-triazin-2-yl)amino]stilbene-2,2'-disulphonate
- EC Number:
- 240-245-2
- EC Name:
- Disodium 4,4'-bis[(4-anilino-6-morpholino-1,3,5-triazin-2-yl)amino]stilbene-2,2'-disulphonate
- Cas Number:
- 16090-02-1
- Molecular formula:
- C40H38N12Na2O8S2
- IUPAC Name:
- disodium 2,2'-ethene-1,2-diylbis{5-[(4-anilino-6-morpholin-4-yl-1,3,5-triazin-2-yl)amino]benzenesulfonate}
Constituent 1
Method
- Type of population:
- general
- Subjects:
- - Number of subjects exposed: 70 subjects.
- Controls:
- The vehicle also was applied as a negative control. No positive control was applied.
- Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST USED: repeated insult patch test.
ADMINISTRATION
- Vehicles: 0.5 %: the detergent base contained sodium alkylbenzenesulphonate, sodium alkyl sulphate, sodium tripolyphosphate, sodium sulphate and minor ingredients including perfumes. Component concentrations were not listed, but were stated as being within ranges of usual commercial formulations.
- Concentration of brightener in vehicle: 10 %.
- Concentration of vehicle applied: in 0.5 % aqueous solution.
- Type of application: occlusive patches
- Applications: series of nine applications, each of 24 hours duration, during a three-week period.
- Challenge: two weeks later the TS application.
EXAMINATIONS
The application sites were graded for primary irritation at intervals during the insult patching sequence.
Results and discussion
- Results of examinations:
- NO. OF PERSONS WITH/OUT REACTIONS COMPARED TO STUDY POPULATION
- Number of subjects with positive reactions: 0
- Number of subjects with negative reactions: 70
- Number of subjects with irritating reactions: 0
The material did not appear to cause irritation. None of the subjects was sensitized.
Applicant's summary and conclusion
- Conclusions:
- 0 sensitized/70 subjects.
The material did not appear to cause irritation. None of the subjects was sensitized. - Executive summary:
Method
The test material (at 0.5 % aqueous solution of a detergent mixture containing 10 % brightener) was applied under occlusive patches in a series of nine applications (each of 24 hours duration) during a 3 week period to 70 human . Challenge applications were made 2 weeks later.
The vehicle also was applied as a negative control. No positive control was applied. The detergent base contained sodium alkylbenzenesulfonate, sodium alkyl sulfate, sodium tripolyphosphate, sodium sulfate and minor ingredients including perfumes. Component concentrations were not listed, but were stated as being within ranges of usual commercial formulations. The test application sites were graded for primary irritation at various intervals.
Results
0 sensitized/70.
The material did not appear to cause irritation. None of the subjects was sensitized.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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