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EC number: 219-291-2 | CAS number: 2403-88-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
NOEL (P, male) > 600 mg/kg/day, NOEL (P, female) = 200mg/kg/day and NOEL (F1) = 200mg/kg/day, GLP-OECD Guideline Study, MHW, 1998
Toxicity to reproduction: other studies
Additional information
Only the results from one study are available. The OECD repeat dose and reproductive toxicity study [OECD TG 422] was reported (MHW, Japan, 1998). This study was identified to be well conducted and reported. With regards to the reproductive performance, no effects were detected in males. However, at estrous cycle examination, continuous diestrous was observed in three females of the 600 mg/kg group and the mean estrous cycle of this group showed extension compared with the control group. There were no effects of the test substance on the copulation or fertility indices. Pathological examinations did not show significant abnormalities in the reproductive organs of the parental animals. With regard to the effects on neonates, viability on day 4 of lactation was decreased in the 600 mg/kg group, and male and female pups of the 600 mg/kg group showed lower body weights on day 4 of lactation. There are no significant differences in the delivery index and live birth index. Also, no exteral and visceral abnormalities related to the test substance were detected in any of the offspring.
Conclusion: On the basis of these findings, the NOEL of 2,2,6,6 -tetramethylpiperidin-4 -ol for reproductive toxicity to parental rats was considered to be > 600 mg/kg/day for males, and 200 mg/kg/day for females. Moreover, the NOEL of the test substance to F1 offspring was established to be 200 mg/kg/day.
Justification for classification or non-classification
Due to the lack of toxicity on reproduction, there is no need to classify 2,2,6,6 -tetramethylpiperidin according to this endpoint.
Additional information
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