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Diss Factsheets
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EC number: 295-835-2 | CAS number: 92129-33-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1971
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
- Objective of study:
- excretion
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- Quaternary ammonium compounds, bis(hydrogenated tallow alkyl)dimethyl, chlorides
- EC Number:
- 263-090-2
- EC Name:
- Quaternary ammonium compounds, bis(hydrogenated tallow alkyl)dimethyl, chlorides
- Cas Number:
- 61789-80-8
- IUPAC Name:
- 61789-80-8
- Reference substance name:
- Dimethyl-di-"hydrogenated tallow" ammonium chloride
- IUPAC Name:
- Dimethyl-di-"hydrogenated tallow" ammonium chloride
- Details on test material:
- Dimethyldihydrogenated tallow ammonium chloride manufactured by the Armour Industrial Chemical Company.
Constituent 1
Constituent 2
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- other: Charles River albino
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Charles River albino rats, obtained from Charles River Breeding Laboratories, Massachusettes. Rats were fed ad libitum. They were housed individually in standard wire-bottomed steel cages.
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- The test substance was provided in the diet at 3 levels. The appropriate amount of test substance was mixed with the standard rat diet ration in a Hobart mixer. Fresh diets were prepared each week, and each rat was offered an amount of diet sufficient for 1 week's ad libitum feeding.
- Duration and frequency of treatment / exposure:
- 91 days, provided daily in the diet. The parents of these rats were also exposed for approximately 4 weeks prior to mating.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 7, 140 and 2800 ppm.
- No. of animals per sex per dose / concentration:
- 3 males and 3 females per dose.
- Control animals:
- yes, plain diet
- Positive control reference chemical:
- Not examined.
- Details on study design:
- A 90 day feeding study was conducted at Industrial BIO-TEST laboratories with groups of rats who were the offspring of previously exposed rats. At the end of the 90 day feeding study, some of the rats were maintained on the diet for an extra 24 hours and housed in metabolism cages for the collection of urine and faeces. Average dose levels per day were calculated based on body weights and individual feed consumption during the last six weeks of the feeding study (see Table 1).
- Details on dosing and sampling:
- 24 hour urine and faeces were collected and frozen separately. The samples were analysed for quarternary compound content at Armour Industrial Chemical Company Laboratories. Samples were extracted with chloroform prior to colorimetry analysis.
- Statistics:
- None reported.
Results and discussion
- Preliminary studies:
- Not applicable.
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Not determined.
- Details on distribution in tissues:
- Not determined.
- Details on excretion:
- Very little test substance was found in the urine from the highest feeding level. Tests on the lower feeding levels were negative within experimental error.
It was necessary to develop a background correction factor for the faecal analysis because each control sample exhibited a different background value. An average of 13% was eliminated in the faeces from the high dose group. Data for the high dose group are shown in Table 2.
Metabolite characterisation studies
- Metabolites identified:
- not measured
Any other information on results incl. tables
Table 2. Test substance excretion data from rats fed 2800 ppm.
Animal No. and Sex |
Average Intake (mg) |
Amount Recovered (mg) |
% Recovered |
|
Faeces |
Urine |
|||
1 M |
64.7 |
5.7 |
0.007 |
8.8 |
2 M |
22.8 |
0.045 |
35.3 |
|
3 M |
2.2 |
0.01 |
3.4 |
|
Average |
15.8 |
|||
4 F |
51.0 |
6.1 |
0.014 |
11.9 |
5 F |
0.5 |
- |
0.9 |
|
6 F |
2.6 |
- |
5.0 |
|
Average |
5.9 |
Applicant's summary and conclusion
- Conclusions:
- The authors concluded that significant amounts of the compound were metabolised by the rats.
- Executive summary:
Albino rats were fed with the test substance in the diet as part of a separate 90 day feeding study (Smith & Plank, 1971). At the end of the study they were maintained on the diet for a further 24 hours for collection of urine and faeces in metabolism cages.
The excretion of the quarternary compound in the urine and faeces was determined by colorimetry following chloroform extraction.
At lower dietary levels (7 and 140 ppm) virtually no quarternary compound was recovered.
At the higher dietary level (2800 ppm) an average of 15% was excreted by males and 5.9% by females, with the majority of excreted compound being found in the faeces.
The authors concluded that significant amounts of the compound were metabolised.
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