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Diss Factsheets
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EC number: 200-712-3 | CAS number: 69-72-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
One study rated Klimisch validity 2 has been selected as key study (Kamaya et al., 2005), since conducted similarly to standardised guidelines and with buffered test solutions. This study led to a 48H-EC50 of 870 mg/l.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 870 mg/L
Additional information
One study rated Klimisch validity 2 has been selected as key study (Kamaya et al., 2005). This study led to a 48H-EC50 of 870 mg/l.
Because of uncertainties on Henschel et al. (1997) data, this has been put in reliability 3 and has not been selected as supporting study. Indeed, the test solutions were not buffered and even if it was indicated that "usual pH values were found in the concentration ranges around the EC50 values", it was not possible to assess how this pH effect may have impacted the calculation of the EC50 value since no information was available on the concentrations tested.
Four other relevant supporting studies of Klimisch validity 2 are also available and listed below:
- a study following OECD guideline 202 "Daphnia sp. acute immobilization test" (Wang and Lay, 1989) => EC50-24h = 230 mg/L (pH = 6.5)
- a study following a french standardized method AFNOR T90301(Dion and Decros, 1984) => 24h-EC50 = 180mg/L at pH 2,3 and 24h-EC50> 1500mg/L at pH 7
- another study following a french standardized method AFNOR T90301 (Palla and Dion, 1983) => 24h-EC50 between 100 (pH=6,5) and 350 mg/L (pH=2,6)
- a study similar to OECD guideline 202 (Bringmann and Kühn, 1982) => 24h-EC50 = 105mg/L and 24h-EC100= 113mg/L (non neutralized solution) 24h EC100>1440mg/L (neutralized solution)
These studies were all performed on 24h of exposure instead as 48h as requested in the OECD guideline, but they were still considered as reliable with restrictions because they support the result obtained in the key study. Moreover, two of these studies have been performed with and without pH adjustment of the test medium. When comparing the results obtained, the effects observed at lower concentrations (i.e. 100 -200 mg/L) can be attributed to the pH instead of the toxic properties of salicylic acid.
Conclusion :
All these studies support the key study for the indication of no hazard of salicylic acid to aquatic invertebrates.
These studies also demonstrate the physical acid effect of non buffered test solution of salicylic acid.
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