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EC number: 273-234-6 | CAS number: 68953-96-8 This substance is identified by SDA Substance Name: C11-C13 branched alkyl benzene sulfonic acid calcium salt and SDA Reporting Number: 25-097-06.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP laboratory study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Branched CaDDBS
- IUPAC Name:
- Branched CaDDBS
- Details on test material:
- Calcium bis(tetrapropylenebenzenesulphonate); CAS No. 11117-11-6
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hoechst AG, Kastengrund, SPF breeding colony
- Age at study initiation: males, approx. 7 weeks; females, approx. 8 weeks
- Weight at study initiation: males, mean = 197 g; females, mean = 193 g
- Fasting period before study: yes
- Housing: Makrolon Type 4 cages on soft wood granulate in groups of 5 animals in fully air-conditioned rooms
- Diet (e.g. ad libitum): ad libitum, Atlromin 1324 rat diet
- Water (e.g. ad libitum): ad libitum, tap water in plastic bottles
- Acclimation period: Not necessary
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 3 C
- Humidity (%): 55 +/- 20%
- Air changes (per hr): Not stated
- Photoperiod (hrs dark / hrs light): 12:12 dark:light
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: sesame oil
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 30 cm2
- Type of wrap if used: aluminum foil held in place with an elastic plaster bandage
REMOVAL OF TEST SUBSTANCE
- Washing (if done): washed with warm water
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 4 mL/kg bw
- Concentration (if solution): 25, 40 and 50% for doses 1000, 1600 and 2000 mg/kg bw, respectively
- Constant volume or concentration used: yes - Duration of exposure:
- 24 hours
- Doses:
- 1000, 1600, and 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 males for each of the 1000 and 1600 mg/kg bw doses; 5 males and 5 females for the 2000 mg/kg bw dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Symptoms and lethality recorded twice per day (morning and afternoon) on weekdays and once daily on weekends and holidays. Animals found dead were dissected as soon as possible and examined fro macroscopically visible changes. During the observation period the animals were weighed weekly.
- Necropsy of survivors performed: yes. Surviving animals were sacrificed at the end of the observation period, dissected, and examined for macroscopically visible changes.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 - < 1 600 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Mortality was observed at doses of 1600 and 2000 mg/kg bw, but not at 1000 mg/kg bw (see table). Lethality was noted only up to day three of the study.
- Clinical signs:
- other: Besides unspecific symptoms, the animals showed impairments of respiration, motility and reflexes. They also exhibited stupor, prone position, trembling, hypothermia, narrowed palpebral fissures, and blood-encrusted snouts. These symptoms disappeared in
- Gross pathology:
- At necropsy, blood in the intestinal tract and diffuse reddening of the stomach mucosa were observed in animals found dead. Light or dark discolorations of the liver occurred in two dead male animals of the 2000 mg/kg bw group. No macroscopically visible changes were observed in surviving animals that were sacrificed at the end of the observation period.
Any other information on results incl. tables
Dose mg/kg bw |
Lethality |
|||
Male |
Female |
|||
Number |
Percent |
Number |
Percent |
|
1000 |
0/5 |
0 |
- |
- |
1600 |
5/5 |
100 |
- |
- |
2000 |
4/5 |
80 |
3/5 |
60 |
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal LD50 of phenylsulfonat CA is between 1000 and 1600 mg/kg bw.
- Executive summary:
The acute dermal toxicity of Branched CaDDBS (Phenylsulfonat CA) was tested in male and female Wistar rats at doses of 1000, 1600 and 2000 mg/kg bw. Lethality was observed in the 1600 and 2000 mg/kg bw doses but not in the 1000 mg/kg bw dose. All lethality had occurred by day three of the post application observation period. Other signs of toxicity included impairments of respiration, motility and reflexes, as well as stupor, prone position, trembling, hypothermia, narrowed palpebral fissures, and blood-encrusted snouts, all of which had disappeared by eight days post application. The skin showed erythema, fine and coarse scales, desquamations and scars, as well as discoloration, induration, chapping, scabbing and lumpiness. No effects on body weight gain were observed. The resultant acute dermal LD50 is >1000 and <1600 mg/kg bw.
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