Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-401-0 | CAS number: 106-47-8
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication which meets basic scientific principles
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Accurate, wide-range, automated, high-performance liquid chromatographic method for the estimation of octanol/water partition coefficients. I: Effect of chromatographic conditions and procedure variables on accuracy and reproducibility of the method
- Author:
- Garst JE, Wilson WC
- Year:
- 1 984
- Bibliographic source:
- Journal of Pharmaceutical Sciences, 73:1616¿1623
- Reference Type:
- review article or handbook
- Title:
- 4-CHLOROANILINE
- Author:
- IPCS-INCHEM
- Year:
- 2 003
- Bibliographic source:
- in: Concise International Chemical Assessment Document 48
- Reference Type:
- review article or handbook
- Title:
- p-Chloranilin
- Author:
- Gesellschaft Deutscher Chemiker (GDCh)
- Year:
- 1 993
- Bibliographic source:
- Beratergremium für umweltrelevante Altstoffe (BUA). Wissenschaftliche Verlagsgesellschaft, BUA-Stoffbericht 153
Materials and methods
- Principles of method if other than guideline:
- Automated Log Pow measurement (ALPM). Definition of terms, the equation for the calculation of ALPM log Pow, and a description of instrumentation, columns, conditions, and procedures are reported in a preceding paper (Garst and Wilson, 1984).
- GLP compliance:
- no
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- 4-chloroaniline
- EC Number:
- 203-401-0
- EC Name:
- 4-chloroaniline
- Cas Number:
- 106-47-8
- Molecular formula:
- C6H6ClN
- IUPAC Name:
- 4-chloroaniline
- Details on test material:
- - Name of test material (as cited in study report): 4-chloroaniline
- Analytical purity: no data
Constituent 1
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- 1.87
Any other information on results incl. tables
Temperature and pH are not reported.
Applicant's summary and conclusion
- Executive summary:
The LogPow of 4 -chloroaniline is 1.87 (Garst and Wilson, 1984).
Temperature and pH are not reported. They are assumed to be taken under normal conditions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
