Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 214-302-7 | CAS number: 1120-24-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- For details on endpoint-specific justification, please see read-across justification document (analogue approach) in section 13.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- assessment report
- Key result
- Water solubility:
- 8.7 g/L
- Temp.:
- 21 °C
- Remarks on result:
- other: Critical micelle concentration
- Details on results:
- The surface tension was plotted against the logarithm of the concentration. The data was fitted with two straight lines in the region of the cmc. The intersection of the lines at 8.7 g/L is taken as the critical micelle concentration. The standard error in the cmc is estimated from the uncertainties of the slopes and positions of the lines to be +/- 0.8 g/L.
The temperature given is the rounded mean of the temperatures at the eleven different concentrations (20.7 °C). - Executive summary:
The study used as source investigated the critical micelle concentration of the test substance C10-DMA HCl (hydrochloride) according to ISO 4311. The study results of the source substance were considered applicable to the target substance. Justification and applicability of the read-across approach (structural analogue) is outlined in the read-across report in section 13.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to OECD Guideline 105
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Type of method:
- flask method
- Key result
- Water solubility:
- 41 mg/L
- Temp.:
- 20 °C
- pH:
- 8.8
- Details on results:
- The water solubility of 41 mg/L and the pH of 8.8 represent the means from three determinations with different equilibration times (see below).
- Conclusions:
- Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The water solubility of the test substance at 20 °C is 41 mg/L. - Executive summary:
The water solubility of the test substance was determined according to the OECD Guideline for the Testing of Chemicals 105. The water solubility at 20 °C is 41 mg/L.
Referenceopen allclose all
Summary of tensiometer outputs and additional details
Concentration [g/L] |
No. of runs |
Mean surface tension [mN/m] |
Std.Dev. surface tension [mN/m] |
Temparature[°C] |
0.03 |
10 |
69.79 |
0.05 |
20.8 |
0.10 |
10 |
64.13 |
0.06 |
20.8 |
0.30 |
10 |
52.96 |
0.09 |
20.8 |
0.55 |
10 |
43.12 |
0.05 |
20.4 |
1.0 |
10 |
32.14 |
0.18 |
20.8 |
3.0 |
10 |
26.82 |
0.11 |
20.8 |
5.5 |
10 |
24.93 |
0.14 |
20.6 |
10.0 |
10 |
24.09 |
0.04 |
20.8 |
15.0 |
10 |
27.12 |
0.04 |
20.6 |
20.0 |
10 |
31.22 |
0.05 |
20.8 |
30.0 |
10 |
33.64 |
0.05 |
20.9 |
Appearance of solutions: clear, homogeneous
Preliminary test:
mL of water for 0.1 g soluble |
0.1 |
0.5 |
1 |
2 |
10 |
100 |
150 |
Approx. solubility in g/L |
>1000 |
1000 to 200 |
200 to 100 |
100 to 50 |
50 to 10 |
10 to 1 |
<1 |
Visual evaluation |
not |
not |
not |
not |
not |
not |
not |
Solubility test:
Flask No. |
Equilibration time [h] |
pH of aqueous |
Test substance |
1 2 3 |
24 48 72 |
9.2 8.9 8.4 |
46 39 39 |
mean |
--- |
--- |
41 |
Individual titration results:
Day |
Volume of aqueous |
Volume of volumetric solution [mL] |
Test substance |
1 |
20 |
0.95 |
46 |
2 |
20 |
0.82 |
39 |
3 |
20 |
0.82 |
39 |
mean |
--- |
--- |
41 |
Description of key information
Water solubility C10-DMA (20 °C; pH 8.8; OECD 105): 41 mg/L
Water solubility C10-DMA hydrochloride (21 °C; CMC acc. to ISO 4311): 8.7 g/L
Key value for chemical safety assessment
- Water solubility:
- 4 370.5 mg/L
- at the temperature of:
- 20 °C
Additional information
Members of the category of dimethylalkylamines (DMAs) are medium strong bases with a pKa of 9.78 (25 °C), independent of the chain length.
In an aqueous system as well as in a physiological medium, a chemical equilibrium between the dimethylalkylamine and the dimethylalkylammonium ion is formed, depending on the prevailing pH. Due to the ionic character, the dimethylalkylammonium ion is of a pronouncedly higher solubility in water compared to the neutral amine. Accordingly, the water solubility of DMAs is strongly dependent on pH, with higher solubility in the neutral and acidic range compared to alkaline pH close or above the pKa. Consequently, the water solubility of the DMA amine is lower than the solubility of the corresponding DMA hydrochloride (DMA HCl). In water, the DMA HCl salt dissolves under slightly acidic reaction, such that the equilibrium is to nearly 100% at the side of the alkylammonium ion. Because of the pKa of 9.78 characteristic for the DMA category, already at neutral pH the equilibrium is at the side of the alkylammonium ion. To take this into account, the key value is given as the arithmetic mean of the water solubility determined with the DMA and the water solubility of the DMA HCl. Because the DMA HCl is surface-active, in lieu of the water solubility the critical micelle concentration (CMC) is given to avoid an overestimation of the water solubility due to the formation of micelles.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.