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EC number: 238-034-5 | CAS number: 14177-55-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20 Apr - 19 May 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Ministére de L'économie de L'industrie et de L'emploi, Secrétariat général du GIPC-DGCIS-SI-12, rue Villiot-75572 Paris cedex 12
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Molybdenum nickel tetraoxide
- EC Number:
- 238-034-5
- EC Name:
- Molybdenum nickel tetraoxide
- Cas Number:
- 14177-55-0
- Molecular formula:
- MoO3*nNiO (with n in a range of 0.6 - 1)
- IUPAC Name:
- Reaction mass of molybdenum oxide and nickel oxide
- Details on test material:
- - Name of test material (as cited in study report): Molybdenum nickel tetraoxide
- CAS No.: 14177-55-0
- Code number: PH-10/0134
- Physical state / appearance: slight yellow powder
- Analytical purity: >99%
- Lot/batch No.: GRA20100315
- Expiration date of the lot/batch: 01 Feb 2012
- Storage condition: room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Elevage JANVIER (53940 Le Genest St Isle - France)
- Age at study initiation: 8 - 10 weeks
- Weight at study initiation: between 183 g and 233 g
- Fasting period before study: Food was removed on D-1 and then redistributed 4 hours after the test item administration
- Housing: by group of three in solid-bottomed clear polycarbonate cages with a stainless steel mesh lid
- Diet (e.g. ad libitum): M20-SDS ad libitum
- Water (e.g. ad libitum): tap water ad libitum
- Acclimation period: at least five days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 - 25° C
- Humidity (%): 30 - 70%
- Air changes (per hr): approx. fifteen per hour
- Photoperiod: 12 hrs dark / hrs light (07.00 -19.00 continuous light)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- distilled water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 2 g or 300 mg of the test item was weighed - distilled water was added in a 10 mL volumetric flask
DOSAGE PREPARATION (if unusual): preparation was magnetically stirred to obtain a yellow solution just before administration - Doses:
- 2000 mg and 300 mg/kg bw
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: systemic examinations were carried out every day for 14 days - animals were weighed on D0 (just before administering the test item) then on D2, D7, and D14.
- Necropsy of survivors performed: yes - (macroscopic observations were entered on individual autopsy sheets; no microscopic examinations)
- Other examinations performed: clinical signs (behavioural or toxic effects on the major physiological functions), body weight (gain), macroscopic examinations of organs
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- It was noted the death of 5 rats treated at 2000 mg/kg b.w. (5/6) on day 2 (one animal), day 3 (three animals), and on day 4 (one animal).
No mortality was noted in the animals treated at 300 mg/kg b.w. - Clinical signs:
- 2000 mg/kg b.w.: Deaths were preceded by an absence or a decrease in spontaneous activity (5/5), in body temperature (1/5) and piloerection (4/5), which appeared only at 48 hours post-dose. The surviving animal dosed at 2000 mg/kg b.w. presented with decrease in spontaneous activity and in muscle tone and piloerection, which appeared only at 48 hours post-dose.
300 mg/kg b.w.: No clinical signs related to the administration of the test item were observed. - Body weight:
- 2000 mg/kg b.w.: A decrease in body weight was also noted in the five animals, which died during the study period: between -4% and -10% on day 2 compared to day 0.
A slight decrease in body weight was noted in the survivng animal on day 2: -4% compared to day 0. The animal recovered a normal body weight on day 7.
300 mg/kg b.w.: The body weight evolution of the animals remained normal throughout the study. - Gross pathology:
- 2000 mg/kg b.w.: The macroscopical examination of the dead animals revealed a swelling of the stomach (5/5), a thickening of the corpus associated with white spots (2/5) or with a dark coloration (red, brown or green) (2/5), a thinning of the forestomach (5/5) and signs linked to rigor mortis (dark brown coloration of the intestines and red coloration of the lungs). The macroscopical examinations of the survivng animal at the end of the study did not reveal treatment related changes.
300 mg/kg b.w.: The macroscopical examination of the animals at the end of the study did not reveal treatment related changes.
Any other information on results incl. tables
The LD50 of the test item Molybdenum nickel tetraoxide is higher than 300 mg/kg body weight by oral route in the rat.
In accordance with the OECD guideline 423, the LD50 cut-off of the test item may be considered as 500 mg/kg body weight by oral route in rats (Colas, 2010).
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information
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