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EC number: 629-695-4 | CAS number: 164383-22-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2 Jan - 16 Jan 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Purity not indicated.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- EPA guidelines OTS Aug. 1982
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- C16-18 evennumbered, C18 unsaturated alkyl nitrile
- EC Number:
- 629-695-4
- Cas Number:
- 164383-22-6
- Molecular formula:
- No molecular formula
- IUPAC Name:
- C16-18 evennumbered, C18 unsaturated alkyl nitrile
- Details on test material:
- Purity: Approx 100% Tallow Nitrile
CAS 61790-28-1
State:Light Yellow liquid
Flash point :180ºc
Density: 0.85
Viscocity at 50ºc = 5mPas
Solubility: Insoluble
Stability: Product stable for one year under normal conditions
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: received from Ace Animals on 12/10/85
- Age at study initiation: approx. 8 wks
- Weight at study initiation: The pretest weight range was 272-298 9 for males and 238-250 g for females.
- Fasting period before study: 16-12 hrs before dosing
- Housing: 5/sex/cage in suspended wire mesh cages. Bedding was placed beneath the cages.
- Diet (e.g. ad libitum): Fresh Purina Rat Chow (Diet #5012)
- Water (e.g. ad libitum):
- Acclimation period:
ENVIRONMENTAL CONDITIONS
- Temperature (°C):" temperature controlled"
- Humidity (%): "humidity controlled"
- Air changes (per hr): not indicated.
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: Animal received 10 Dec 1985. Test From: 2 Jan 1986 To: 16 Jan 1986
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Single dosing by syringe and dosing needle.
- Doses:
- 5.0 g/kg.
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: 1, 2 and 4 hours post dose and once each morning and afternoon thereafter for 14 days for mortality toxicity and pharmacological effects.
- Frequency of weighing: Body weights were recorded immediately pretest, weekly, and at termination in the survivors.
- Necropsy of survivors performed: yes: All animals were examined for gross pathology. Abnormal tissues were preserved in 10% buffered formalin for possible future microscopic examination. - Statistics:
- Not applicable as no mortality occurred. The LD 50 was considered to be greater than 5.0 g/kg if there was no compound related mortality at the 5.0 g/kg level.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality at limit dose
- Mortality:
- No mortality occurred
- Clinical signs:
- other: Oily appearance of body surfaces were noted during the study, and one male animal had respiratory rales on Day 6. All animals appeared normal from Day 7 through Day 14.
- Gross pathology:
- Eight animals (5 males and 3 females) were normal. In two females abnormalities were noted: One showed few yellow areas on the intestines, and an abnormality of the left ovary in another animal.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- No mortally, and only limited toxicity occurred at 5 mg/kg bw
- Executive summary:
In a standard LD50 limit study, no mortality was observed following the oral application of 5 g/kg of tallow nitrile to 5 male and 5 female rats. Only limited toxicity was observed consisting of oiily appearance of body surfaces were noted during the study, and one male animal had respiratory rales on Day 6. All animals appeared normal from Day 7 through Day 14.
One female showed a decrease of BW in the course of the second week. All other body weights were normal.
At necropsy 14 days after dosing one female showed few yellow areas on the intestines, and an abnormality of the left ovary was noted in another animal.
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