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EC number: 237-574-9 | CAS number: 13845-36-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
See read-across justification report under Section 13 ‘Assessment Reports’.
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
In accordance with REACH Annex XI, Section 1.5, of Regulation (EC) No. 1907/2006 (REACH) the standard testing regime may be adapted in cases where a grouping or read-across approach has been applied.
The similarities may be based on:
(1) a common functional group
(2) the common precursors and/or the likelihood of common breakdown products via physical or biological processes, which result in structurally similar chemicals; or
(3) a constant pattern in the changing of the potency of the properties across the category
1. Both substances are inorganic salts of a monovalent cation from Group 1A of the periodic table, and triphosphoric acid. Thus, they share the Na+ or K+ cation and P3O105- anion.
2. Both substances will ultimately dissociate into the common breakdown products of the Na+ or K+ cations and the P3O105- anion, resulting in further breakdown products of pyrophosphate and orthophosphate anions.
3. Sodium and potassium cations are ubiquitous in natural waters and are considered to possess similar toxicological and ecotoxicological profiles due in part to their similar behaviour and their existence as essential micronutrients. The triphosphate anion in both substances will breakdown in the environment via the processes of hydrolysis, biotic degradation and assimilation by organisms in the environment, resulting in the breakdown products of pyrophosphate and orthophosphate anions. Ultimately, pyrophosphate anions will also breakdown to orthophosphate. It is therefore considered to be scientifically unjustified to conduct further testing on pentapotassium triphosphate as the read across can be adequately justified.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
See read-across justification report under Section 13 ‘Assessment Reports’.
3. ANALOGUE APPROACH JUSTIFICATION
See read-across justification report under Section 13 ‘Assessment Reports’.
4. DATA MATRIX
See read-across justification report under Section 13 ‘Assessment Reports’. - Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- according to guideline
- Guideline:
- other: TSCA guideline: 40 CFR 797.1930
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- not specified
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Source: Stock culture maintained at testing laboratory
- Age at study initiation: <24 h old - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 186 mg/L (as calcium carbonate)
- Test temperature:
- 20 - 21 C
- pH:
- 8.0 - 8.3
- Dissolved oxygen:
- 8.3 - 9.7 mg/L
- Salinity:
- not applicable
- Nominal and measured concentrations:
- Nominal concentration of 100 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: Cylindrical glass exposure chambers (100mm diameter x 50 mm height). 250 ml fill volume.
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 3
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Well water located at test facility, passed through a mixed bed deionization resin and then reconstituted with sodium bicarbonate, calcium sulfate, magnesium sulfate and potassium chloride.
- Pesticides: Organochlorine & PCBs (< 0.006 µg/L); Organophosphate (< 0.088 µg/L)
- Alkalinity: 119 mg/L as calcium carbonate
- Conductivity (µmhos/cm): 370
OTHER TEST CONDITIONS
- Photoperiod: 16 h light and 8 hour dark
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Observed daily for immobilization (upon prodding) and any behavioural changes
TEST CONCENTRATIONS
- Range finding study conducted at a test concentration of 1000 mg/L (results used to determine the conditions for the definitive study)
-Definitive study conducted at a test concentration of 100 mg/L - Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Reported statistics and error estimates:
- Statistical analysis (t-test) of data indicated there was no significant (alpha = 0.05) difference between the number of daphnids immobilized in control and treatment exposures.
- Validity criteria fulfilled:
- yes
- Conclusions:
- LC50 = >100 mg/L
After 48 hours the LC50 of sodium tripolyphosphate to (freshwater) Daphnia manga was found to be >100 mg/L.
Read across from pentasodium triphosphate to pentapotassium triphosphate is justified on the following basis:
Both substances are inorganic compounds containing a triphosphate anion and a group 1 alkali metal cation. Both sodium and potassium cations are ubiquitous in natural waters and are considered to possess similar toxicological and ecotoxicological profiles due in part to their similar behaviour and their existence as essential micronutrients. The triphosphate anion in both substances will breakdown in the environment via the processes of hydrolysis, biotic degradation and assimilation by organisms in the environment, resulting in the breakdown products of pyrophosphate and orthophosphate anions. Ultimately, pyrophosphate anions will also breakdown to orthophosphate.
It is therefore considered to be scientifically unjustified to conduct further testing on pentapotassium triphosphate as the read across can be adequately justified
Read-across is justified on the basis detailed in rationale for reliability above. This study is therefore considered to be of sufficient adequacy and reliability to be used as a key study for the derivation of the PNECaqua marine. No further testing is justified.
Reference
Table 1: Immobilization of Daphnia magna exposed to sodium tripolyphosphate in a 48 h static acute toxicity test
Nominal concentration (mg/L) of tripolyphosphatea |
Cumulative number of immobilized organisms and corresponding percent (parenthetic value) |
|
24 h |
48 h |
|
0 (control) |
0 (0) |
0 (0) |
100 |
0 (0) |
1 (3) |
aCalculated based on 100% purity of the test substance
Description of key information
Six studies on aquatic invertebrates are available. Three of which are considered reliable. Although the study by Vaishnav et al (1991) only used one test concentration, results from this study gave the most conservative result and this is therefore considered the key study.
Statistical analysis (t-test) of data indicated there was no significant (alpha = 0.05) difference between the number of daphnids immobilized in control and treatment exposures. The study was conducted on the analogous material pentasodium triphosphate (sodium tripolyphosphate).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
The two studies performed by Pandard on the analogous substance sodium tripolpyhosphate (pentasodium triphosphate) exhibited precipitation in the test media throughout the duration of the test. This precipitation is deemed to have interfered with the test organisms and the results are therefore considered unreliable. These tests (Pandard) will not be considered beyond this section of the dossier and are only included for completeness.
Read across from pentasodium triphosphate to pentapotassium triphosphate is justified on the following basis:
Both substances are inorganic compounds containing a triphosphate anion and a group 1 alkali metal cation. Both sodium and potassium cations are ubiquitous in natural waters and are considered to possess similar toxicological and ecotoxicological profiles due in part to their similar behaviour and their existence as essential micronutrients. The triphosphate anion in both substances will breakdown in the environment via the processes of hydrolysis, biotic degradation and assimilation by organisms in the environment, resulting in the breakdown products of pyrophosphate and orthophosphate anions. Ultimately, pyrophosphate anions will also breakdown to orthophosphate.
It is therefore considered to be scientifically unjustified to conduct further testing on pentapotassium triphosphate as the read across can be adequately justified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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