Registration Dossier
Registration Dossier
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EC number: 236-671-3 | CAS number: 13463-41-7
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- BCF (aquatic species):
- 1.4 dimensionless
Additional information
The information contained within this robust summary document comes from studies which are in the ownership of Arch Chemicals Inc. and which are protected in several regions globally. This information may not be used for any purpose other than in support of the Chemical safety Report submitted by Arch Chemicals Inc. under RegulationEC 1907/2006.
To determine if the compound has a potential to bioaccumulate, two bioconcentration studies were done—one with zinc pyrithione in the oyster(Ward & Boeri, 2001) and one with pyrithione compounds in carp (Saito, 1994). Radiolabelled testsubstance was used in each study, and the results were based on the total radioactivity in the tissues. As a result, the bioconcentration factors account for the tissue concentrations of pyrithione plus any metabolites that may have formed.
Calculation of the predicted log BCF using the log Kow of 0.99 for zinc pyrithione in the formula in the oyster:
log BCFfish= 0.85 • log Kow − 0.70
yields the value of 0.14 for log BCF and 1.4 for the BCF.
Calculation of the predicted log BCF using the log Kow of 2.44 for the pyrithione compound in the formula:
log BCFfish= 0.85 • log Kow − 0.70
yields the value of 1.4 for log BCF and 24 for BCF.
The experimental BCF values for pyrithiones in two aquatic species are similar and range from 4.2 to 13.8 (log BCF = 0.6-1.1). This range is approximately two orders of magnitude lower than the log BCF value of 3.0, above which bioconcentration is generally considered to be of concern. This, combined with rapid degradation of pyrithione seen in natural aquatic systems, indicates that zinc pyrithione is unlikely to bioaccumulate in aquatic species, either directly or through the food chain.
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