Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 217-168-8 | CAS number: 1761-71-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- other: case report
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This is case report of adverse effects in an occupational setting. It is reliable with restrictions that no cause and effect can be proven with this information.
Data source
Reference
- Reference Type:
- publication
- Title:
- Allergic Contact Dermatitis from dicyclohexylmethane-4,4'-diisocyanate
- Author:
- Frick M, Björkner B, Hamnerius N, Zimerson E.
- Year:
- 2 003
- Bibliographic source:
- Contact Dermatitis. 48(6): 305-9
Materials and methods
- Study type:
- other: case report
- Endpoint addressed:
- skin irritation / corrosion
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Case report. No guideline is available.
- GLP compliance:
- no
Test material
- Reference substance name:
- 1761-71-6
- IUPAC Name:
- 1761-71-6
- Reference substance name:
- 4,4'-methylenebis(cyclohexylamine)
- EC Number:
- 217-168-8
- EC Name:
- 4,4'-methylenebis(cyclohexylamine)
- Cas Number:
- 1761-71-3
- Molecular formula:
- C13H26N2
- IUPAC Name:
- 4,4'-methylenedicyclohexanamine
- Details on test material:
- no data on purity
Constituent 1
Constituent 2
Method
- Type of population:
- occupational
- Ethical approval:
- not applicable
- Details on study design:
- Employees referred for medical evaluation of adverse effects were patch tested with the standard European series supplemented with several additional chemicals, including DMDI (1% w/w petrolatum) and PACM (0.1% or 0.5% in petrolatum), using a Finn chamber with Scanpor tape. Tests were removed after 2 days and read after 1 day, according to standard (ICDRG) criteria. In 7 (of 16) cases, a second reading was done 7 days after the initial application of patches.
Results and discussion
- Results:
- Contact allergy was demonstrated from occupational exposure to a glue containing isocyanates. A minor component of the glue mixture is 4,4'-methylenedicyclohexanamine (PACM). The substance which was demonstrated in later skin testing to be mainly responsible was isocyanate dicyclohexylmethane-4,4'diisocyanate. None of these patients (13 of 100) reacted to the other constituent, toluene diisocyante (TDI). Five patients showed simultaneous reactions to DMDI and DMDA (PACM). Nine patients also reacted to 1,6-hexamethylenediisocyanate (HDI), 4 to isophoronediisocyanate (IPDI), 1 to isophorone diamine (IPDA) and 5 to MDA. In 4 patients no work- or isocyanate-related allergy could be demonstrated.
Applicant's summary and conclusion
- Conclusions:
- Contact allergy has been demonstrated from occupational exposure to a glue containing isocyanates. A minor component of the glue mixture is 4,4'-methylenedicyclohexanamine (PACM). The substance which was demonstrated in later skin testing to be mainly responsible was isocyanate dicyclohexylmethane-4,4'diisocyanate (DMDI). Five (of 16) reactive patients showed simultaneous reactions to DMDI and DMDA (PACM). As isocyanates are known to be strong dermal sensitisers, this study suggests that components of epoxy resins other than PACM may be the cause of adverse dermal effects.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.