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Diss Factsheets
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EC number: 270-772-3 | CAS number: 68477-90-7 A complex combination of hydrocarbons produced by the distillation of products from the gas and gasoline fractions of a catalytic cracking process. It consists predominantly of propylene with some ethane and propane.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, non-guideline, animal and human experimental study, predates implementation of GLP and/or development of study guidelines but otherwise acceptable for assessment
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Studies on the inhalation of 1,3-butadiene; with a comparison of its narcotic effect with benzol, toluol and styrene, and a note on the elimination of styrene by the human
- Author:
- Carpenter CP, Shaffer CB, Weir CS, Smyth HF
- Year:
- 1 944
- Bibliographic source:
- J Ind Hyg Toxicol 26; 69-78
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Female dogs and male and female rabbits were exposed to 0, 600, 2300 and 6700 ppm 1,3-butadiene for 8 months (7.5h/day, 6 days/week). Eyes were examined prior to, during and after exposure. Eyes were taken at post mortem and examined histopathologically.
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,3-Butadiene
- Cas Number:
- 106-99-0
- Molecular formula:
- C4H6
- IUPAC Name:
- 1,3-Butadiene
- Details on test material:
- Supplied by: Carbide and Carbon Chemicals Corporation
Constituent 1
Test animals / tissue source
- Species:
- other: Dog and rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- no details available
Test system
- Vehicle:
- other: air
- Controls:
- yes
- Amount / concentration applied:
- Concentrated chemical applied
- Duration of treatment / exposure:
- 8 months
- Observation period (in vivo):
- 8 months
- Number of animals or in vitro replicates:
- 1 female dog/group (4 in total); 2 male and 2 female rabbits/group (8 male and 8 female in total)
- Details on study design:
- EXPOSURE: Exposure chambers of 546 L capacity, constructed of masonite and coated with a Bakelite varnish were used. The airflow ranged from 100-190 L/min, which resulted in 10-20 complete changes of air/hour. 1,3-Butadiene was metered directly from a cylinder through a reducing valve and capillary flowrneter, and added to the dilution air being drawn into the chamber from the room. The highest concentration used for repeated exposure approximated one-third of the lower explosive limit.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Remarks:
- qualitative ophthalmoscopic and histopathological examination
- Time point:
- other: 8 months
- Remarks on result:
- other: no signs of irritation in dogs or rabbits, no effects on the cornea, sclera, or ciliary body, no degeneration of the retinal ganglion
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritant / corrosive response data:
- no irritation
- Other effects:
- none
Any other information on results incl. tables
Ophthalmoscopic examination revealed no signs of irritation in dogs or rabbits. Histopathological examination revealed no effects on the cornea, sclera, or ciliary body. None of the sections showed any indication of degeneration of the retinal ganglion cells, and the other retinal layers displayed no abnormality. Sections of the optic nerve with adjacent retina stained with osmic acid showed no degeneration of myelin sheaths.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- 1,3-Butadiene is non irritant to the rabbit and dog eye following exposure to 1,3-butadiene for 8 months at concentrations up to 6700 ppm ( 14824 mg/m3)..
- Executive summary:
Dogs and rabbits were exposed to 1,3-butadiene for 8 months at concentrations of 600, 2300 and 6700 ppm (1327, 5098 and 14824 mg/m3) and eyes examined. No irritation to the eyes of the dogs or rabbits occurred at any doses.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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