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Diss Factsheets
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EC number: 200-898-6 | CAS number: 75-75-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions (lack of detailed documentation)
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
- Reference Type:
- review article or handbook
- Title:
- Methanesulfonic acid.
- Author:
- Shertzer HG
- Year:
- 2 001
- Bibliographic source:
- Patty's Toxicology, 5th edition, Vol 7, Ch. 94: 745-746
- Reference Type:
- publication
- Title:
- HPVIS, IUCLID Data Set for Methanesulphonic acid, CAS no. 75-75-2
- Author:
- US-EPA
- Year:
- 2 003
- Bibliographic source:
- HPV Chemicals Challenge Program OPPT NCIC 201-14249B
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- lack of detailed documentation
- Principles of method if other than guideline:
- Single administration of 0.1 ml of the test substance was placed in the conjuctival sac of one eye of each of two rabbits. The treated eye of one of the two animals was rinsed with flowing water (initiated 20 to 30 seconds after instillation and continued for one minute). The treated eye of the other animal was kept unwashed. The reaction was then scored periodically for 7 days.
- GLP compliance:
- no
Test material
- Reference substance name:
- Methanesulphonic acid
- EC Number:
- 200-898-6
- EC Name:
- Methanesulphonic acid
- Cas Number:
- 75-75-2
- Molecular formula:
- CH4O3S
- IUPAC Name:
- methanesulfonic acid
- Details on test material:
- - Name of test material (as cited in study report): Methanesulfonic acid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eyes served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml
- Concentration (if solution): undiluted (anhydrous solution) - Duration of treatment / exposure:
- eye of one rabbit was washed out after 20 seconds and eye of another rabbit was not washed out
- Observation period (in vivo):
- 7 days (the reaction was abserved at 10 min, 1h, 2h, 3h, 4h, 24h, 48h, 72h, 4 days, 5 days, 6 days and 7 days)
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: with flowing water for 1 minute (only one animal)
- Time after start of exposure: 20 seconds
SCORING SYSTEM: irritation responses were scored (no data on scoring system)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Remarks:
- unwashed eye
- Time point:
- other: 24-48-72 h
- Score:
- 4
- Reversibility:
- not fully reversible within: 21 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Remarks:
- unwashed eye
- Time point:
- other: 24-48-72 h
- Score:
- 0
- Reversibility:
- other: no effects
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Remarks:
- washed eye
- Time point:
- other: 24-48-72 h
- Score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Remarks:
- washed eye
- Time point:
- other: unwashed eye
- Score:
- 0
- Reversibility:
- other: no effects
- Irritant / corrosive response data:
- Unwashed eye:
The reaction involved all ocular tissues and occured immediately. The conjunctivae became completely necrotic (white) without evident swelling. The iris was dilated with ragged edges and failed to react to light. The cornea opacified completely within 24 hours.
Washed eye:
The reaction did not differ significantly from that of the unwashed eye. - Other effects:
- Each instillation caused excruciating pain.
Any other information on results incl. tables
Irritation scores:
Time |
Unwashed eye |
Washed eye |
||||||
Cornea |
Iris |
Redness |
Chemosis |
Cornea |
Iris |
Redness |
Chemosis |
|
10 min |
2 |
2 |
N |
0 |
2 |
2 |
N |
0 |
1 h |
2 |
2 |
N |
0 |
2 |
2 |
N |
0 |
2 h |
2 |
2 |
N |
0 |
4 |
? |
N |
0 |
3 h |
2 |
2 |
N |
0 |
4 |
? |
N |
0 |
4 h |
2 |
2 |
N |
0 |
4 |
? |
N |
0 |
24 h |
4 |
? |
N |
0 |
4 |
? |
N |
0 |
48 h |
4 |
? |
N |
0 |
4 |
? |
N |
0D |
72 h |
4 |
? |
N |
0 |
4 |
? |
N |
0D |
4 days |
4 |
? |
N |
0 |
4 |
? |
N |
0D |
5 days |
4 |
? |
N |
0 |
4 |
? |
N |
0D |
6 days |
4 |
? |
N |
0 |
4 |
? |
N |
0D |
7 days |
4 |
? |
N |
0 |
4 |
? |
N |
0D |
N: total necrosis
D: discharge
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.