Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-102-5 | CAS number: 7439-93-2
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- genetic toxicity in vivo, other
- Remarks:
- Review article. Several kinds of genotoxicity indicated.
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Some of the summarized reports did not contain the complete data for a sufficient evaluation, e.g. frequency of various types of aberrations was not specified and the significance of the increases were not given in the study.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Published data. No guideline indicated.
- Type of assay:
- other: Review article. Several kinds of genotoxicity studies indicated.
Test material
- Reference substance name:
- Lithium hydroxide
- EC Number:
- 215-183-4
- EC Name:
- Lithium hydroxide
- Cas Number:
- 1310-65-2
- Molecular formula:
- LiOH
- IUPAC Name:
- Lithium hydroxide
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Based on data of multiple mutagenicity tests with a variety of lithium salts it is concluded that lithium salts lack mutagenicity.
Consequently, lithium, being the toxicological relevant moiety has not to be considered as a genotoxic or clastogenic substance. - Executive summary:
The authors summarized the results of in vitro and in vivo mutagenicity , DNA damage , CA and SCE tests with various lithium salts. Several studies reported genotoxic effects of various lithium compounds at high doses (equivalent to therapeutic doses or higher), whereas many other studies have failed to demonstrate an effect. The Nordic Expert Group stated, that considering the chemical properties of the lithium compounds it is unlikely that they act as direct mutagens. A possible explanation to the genotoxicity observed might be a secondary effect of increased cell survival caused by lithium’s inhibition of GSK3.
Based on the conclusion of the authors, lithium hydroxide (formed following contact of lithium with aqueous solutions) and thereby lithium (in a read across approach) could be considered not genotoxic or clastogenic substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
