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EC number: 222-583-2 | CAS number: 3542-36-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- not reported
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No data on GLP or if test is performed to regonsised method. No information of purity.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
- Type of study / information:
- Effect of iv enjection of test substance.
Variety of in vitro tests using rat cells.
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dichlorodioctylstannane
- EC Number:
- 222-583-2
- EC Name:
- Dichlorodioctylstannane
- Cas Number:
- 3542-36-7
- Molecular formula:
- C16H34Cl2Sn
- IUPAC Name:
- dichlorodioctylstannane
Constituent 1
Results and discussion
Any other information on results incl. tables
Cell viability studies
In the presence of graded amounts of DOTC, thymocyte survival decreased in a dose related and time-dependent fashion when compared with the thymocyte loss in the control cultures. After a 24-hr incubation with 50 µg DOTC, survival was only some 25-30% of the control values. With concentrations of 0.5 µg/ml (1.2 µM-DOTC), thymocyte survival still showed a considerable decrease.
Lymphocyte Transformation
The blast transformation of thymocytes was inhibited in a dose-related manner in the presence of graded concentrations of DOTC. In concentrations of 0.5 µg DOTC/ml incorporation was completely inhibited.
DOTC was shown to have similar effects on the transformation of lymphocytes from the spleen as on those from the thymus. and again the effects were similar in PHA- and Con A-stimulated cultures and also in splenocyte cultures incubated with LPS.
Glucose metabolism studies
Glucose uptake showed some increase at a concentration of only 5 µM. Maximal stimulation of glucose consumption occurred at 120 µM for DOTC further increases in the exposure levels progressively decreased glucose consumption.
The increased amount of glucose consumed by thymocytes incubated with DOTC was not completely metabolized but was largely converted to lactate and pyruvate. Thus conversion is mainly by the glycolytic pathway, with little oxidation by the TCA cycle. Lactate and pyruvate production was stimulated maximally at the concentration of DOTC that also induced maximum glucose consumption.
The oxygen consumption of the thymocytes showed a slight, but dose-related, decrease in incubations with the test compound. At maximum stimulation of the substrate uptake. Oxygen consumption was never reduced by more than 30%, and at lower organotin concentrations it was only slightly diminished. This is notable, since the accumulation of lactate and pyruvate showed that the increased amount of glucose consumed undergoes little oxidative metabolism.
At organotin levels up to those inducing maximum stimulation of the substrate consumption. the number and viability of rat thymocytes was not affected during the 4-hr incubation period. Cell survival declined at higher exposure levels but after a 4-hr incubation it was never reduced by more than 10% when scored with nigrosin exclusion.
Applicant's summary and conclusion
- Conclusions:
- DOTC induces lymphcytotoxicity both in vitro and in vivo.
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