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EC number: 270-299-2 | CAS number: 68424-38-4 This substance is identified by SDA Substance Name: C16-C18 alkyl carboxylic acid sodium salt and SDA Reporting Number: 19-006-04.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
- no carcinogenic effects | Rat (male/female) | OECD 453 | oleic acid
- no carcinogenic effects | Rat (male/female) | OECD 451 | sodium oleate
Key value for chemical safety assessment
Justification for classification or non-classification
Additional information
The chronic toxicity and carcinogenicity of sodium oleate and oleic acid were examined in Fisher 344 rats of both sexes. The rats were divided into three groups: Group I was given 5% test substance, and group II was given 2.5% test substance in their drinking water. Group III was the control group. All rats were fed this mixture for two years.
Urine alnalysis, serological and haematological tests did not reveal any significant changes in comparison to the control group.
The weight check of the organs among male rats revealed that the liver of the rats in the high concentration group weighed less than that of the controll group, and the thymus gland of the female rats was the heaviest.
In both experiments with sodium oleate and oleic acid, tumors developed in various organs. The question needs to be answered as to wether this development was caused by the substances tested or occurred spontaneously. In the case of male rats the development of tumors in this experiments occured in 96% of the high concentration group, 100% of the low concentration group and 98% of the control group, whereas in the case of female rats it occured in 56% of the high concentration group, 72% of the low concentration group and 56% of the control group.
The development of tumors shows no significantly greater incidence than the natural incidence of tumors, so that sodium oleate is not found to be carcinogenic. If we compare the individual tumors of this experiments with the naturally occuring tumors, pituritary tumors occured fairly often among male rats. Insulinoma of the spleen did not occur among the control groups, although in 8.4% there were cases of natural development, so that it can hardly be claimed that this is a tumor, which developed due to the tested substances. Among the female rats the incidence of pituitary tumors is about the same as in the case of natural development. C-cell adenoma of the thyroid gland also occured quite often, and the rate of incidence of tumors in the reproductive organs and mammary glands was about the same.
From the above results no carcinogenic effects of the long-term administration of sodium oleate and oleic acid can be detected. the tumors which developed cannot be attributed to the substances tested, but have to be considered tumors which develops naturally.
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