Registration Dossier
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EC number: 214-254-7 | CAS number: 1117-86-8
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to international guideline(s), GLP-compliant, performed in recognized contract research organization, no restrictions, fully adequate for assessment.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 7.5 g/L
- Temp.:
- 20 °C
- pH:
- 6.3
- Remarks on result:
- other: Standard deviation: 0.15 mg/L, corresponding to a relative standard deviation of 2.1 % (n=5)
- Details on results:
- The water solubility of the test item was not temperature dependent. The difference between the measured concentrations of dissolved test item in two flasks incubated at 4.6 and 20 °C, was < 3%/°C. Thus, the main study was performed at 20 °C only.
- Conclusions:
- Interpretation of results (migrated information): soluble (1000-10000 mg/L)
Reference
Table 2: Detailed results
Flask |
4 |
5 |
6 |
|||
Nominal concentration (g/L) |
8.0 |
9.5 |
11.0 |
|||
pH |
6.33 |
6.31 |
6.27 |
|||
Area (pA*s; measured value) |
405.1 401.5 |
433.7 398.7 |
451.5 488.2 |
439.3 418.9 |
416.3 406.2 |
381.5 393.2 |
Concentration Test Item (mg/L; diluted sample) |
64.1 63.8 |
66.6 63.6 |
68.1 71.3 |
67.1 65.3 |
65.1 64.2 |
62.1 63.1 |
Dilution factor |
100 |
|||||
Recovery rate in % |
86 |
|||||
Concentration Test Item (g/L) |
7.44 |
7.57 |
8.10* |
7.70 |
7.52 |
7.58 |
Mean value ± standard deviation |
7.5 ± 0.15 g/L |
|||||
* This value showed great deviation from the other values and was not used in the calculation of the mean.
The concentration of the test item was determined using the following equation: y = 11.68733116 * x - 344.5630615
Description of key information
7.5 g/L at 20 °C, pH 6.3 (OECD 105 and EU A.6)
Key value for chemical safety assessment
- Water solubility:
- 7.5 g/L
- at the temperature of:
- 20 °C
Additional information
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