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EC number: 204-435-9 | CAS number: 120-92-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Purity of the test substance was not reported even if the cyclopentanone was received from Esso Research and Engineering and was considered to be free from impurities. The study was performed before the GLP standard was established. However, the method and the results were quite well described. The exposure chamber concentrations were nominal dosage concentrations. The LC50 was estimated because mortality data were not suitable for statistical analysis.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- other: no data
- Limit test:
- no
Test material
- Reference substance name:
- Cyclopentanone
- EC Number:
- 204-435-9
- EC Name:
- Cyclopentanone
- Cas Number:
- 120-92-3
- Molecular formula:
- C5H8O
- IUPAC Name:
- cyclopentanone
- Details on test material:
- Cyclopentanone from Esso research and Engineering Company
- Test material identity: Cyclopentanone (MRD-64-20)
- Details on test material: no other information are available
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS:
- Weight at study initiation: 200 - 225 g
- Housing: Animals were housed in wiremesh cages centred in the
stainless steel exposure chamber.
- Source, age at study initiation, fasting period before study, diet, water, acclimation period: data not available
ENVIRONMENTAL CONDITIONS (temperature, humidity, air changes, photoperiod): data not available.
IN-LIFE DATES: data not available.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
inhalation exposure to vapours was carried out in a dynamic, 500 litres, stainless steel exposure chamber.
Vaporization of the cyclopentanone was achieved by means of delivering predetermined amounts of the liquid test substance by a metering pump
into a stainless steel spray nozzle tip operating under positive air pressure.
The cyclopentanone metered through the nozzle were then vaporized by the pressurized air flow directly into the exposure chamber.
Nominal dosage concentrations were calculated from the amount of liquid being metered and the total airflow through the chamber.
TEST ATMOSPHERE: data not available - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- 4.7, 12, 15, 17.8, 19.5 mg/L
- No. of animals per sex per dose:
- 10 male rats per group
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: mortality and signs of toxicity were observed at half-hour intervals during the actual exposure and daily during a 14-day post-exposure observation period.
- Necropsy of survivors performed: yes - Statistics:
- no data available
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- >= 19.5 mg/L air
- Exp. duration:
- 4 h
- Remarks on result:
- other: 95% CL: results not suitable for statistical analysis
- Mortality:
- Groups of animals were exposed to test concentrations of 4.7, 12, 15, 17.8 or 19.5mg/L, resulting in the following cumulative mortality data
(no. animals dead/no. animals tested): 0/10, 1/10, 3/10, 3/10 and 4/10, respectively.
All animals survived the exposure period, with deaths occurring during the 14 day observation period. - Clinical signs:
- other: During exposure, dyspnea, depression and decreased activity were observed. Moreover, ataxia and prostration were also noted at the two highest levels. These signs disappeared within 48 hours.
- Body weight:
- no data available
- Gross pathology:
- Autopsy of dead animals showed moderate congestion of the lungs, liver and kidneys. No gross findings were noted from autopsies at the end of the study.
Any other information on results incl. tables
Copy of Exxon's submission to EPA of test data on Isophorone & cyclopentanone. LC50 studies in rats were reported.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In this study, no mortality were observed in male rats at 4.7, 12, 15 mg/L of cyclopentanone.
Three and 4 rats died respectivelly after 17.8 and 19.5 mg/L. - Executive summary:
In an acute inhalation toxicity study (Anon., 1965), groups of Wistar rats (10 males/group) were exposed by inhalation (whole body) to cyclopentanone (purity unknown) for 4 hours at concentrations of 4.7, 12, 15,n 17.8, 19.5 mg/L.
Animals then were observed for 14 days.
No mortality were observed in male rats at 4.7, 12, 15 mg/L of cyclopentanone. Three and 4 rats died respectivelly after 17.8 and 19.5 mg/L.
Based on these results a LC50 for male rats was identified. LC50 (male rats) >= 19.5 mg/L
Cyclopentanone is classified as being of LOW Toxicity based on male results.
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