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EC number: 939-382-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- other: experimental result on similar substance
- Adequacy of study:
- key study
- Study period:
- September and October 1990
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Similar substance 03
- IUPAC Name:
- Similar substance 03
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: HanIbm: WIST (SPF)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: BRL, Biological Research Laboratories Ltd., Fullinsdorf
- Age at study initiation: 10 weeks males and 12 weeks females
- Weight at study initiation: males: 211-243 g; females: 189-205 g
- Identification: by unique cage number and corresponding colour coded spots on the tail
- Randomization: randomly selected at time of delivery
- Housing: individually in Makrolon type-8 cages with standard softwook bedding ("Lignocel", Schill AG, Muttenz)
- Diet: certificated pelleted standard Kliba 343, Batch 74/90 rat maintenance diet ("Kliba", Klingentalmuehle AG, Kaiseraugust) ad libitum.
- Water: community tap water from Itingen, ad libitum. Bacteriological assay, contaminant and chemical analysis were performed.
- Acclimation period: September 27 to October 3, 1990, one week under laboratory conditions after veterinary examination
ENVIRONMENTAL CONDITIONS
Hourly monitored
- Temperature: 22 ± 3°C
- Humidity: 40-70%
- Air changes: air-conditioned with 10-15 changes per hour
- Photoperiod: 12 hours artificial fluorescent light/12 hours dark, music during the light
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- other: bi-distilled water
- Details on dermal exposure:
- TEST SITE
- Area of exposure: approximately 24 hours before treatment, the backs of the animals were clipped with an electric clipper
- % coverage: approximately 10% of the total body surface
- Type of wrap if used: On test day 1, the test article was applied evenly on the skin with a syringe and covered with a semi-occlusive dressing. the dressing was wrapped around the abdomen and fixed with an elastic adhesive bandage
REMOVAL OF TEST SUBSTANCE
- Washing: with lukewarm tap water
- Dry: with disposable paper towels
- Time after start of exposure: 24 hours
TEST ARTICLE PREPARATION
The test article was placed into a glass breaker on a tered Mattler PE 360 balance and the vehicle (bi-distilled water) was added. A weight/volume dilution was prepared using homogenizer.
Homogeneity of the test article was maintained during treatment using a magnetic stirrer.
The preparation was made immediately prior to dosing.
APPLICATION SUBSTANCE
- Application volume/kg bw: 4 ml at 2000 mg/kg - Duration of exposure:
- 24 hours; 24 hours after application, the dressing was removed.
- Doses:
- A single dose of 2000 mg/kg
- No. of animals per sex per dose:
- 5 male and 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 15 days
- Frequency of observations and weighing:
Mortality: four times during the test day 1 and daily during days 2-15;
Body Weights: test days 1 (pre-administration), 8 and 15
- Necropsy of survivors performed: yes performed by experienced prosectors; all animals were necropsied. All animals surviving to the end of the observation period were euthanized by intraperitoneal injection of sodium pentobarbitone
- Other examinations performed:
Clinical signs: Each animal had an examination for changes in appearance and behaviour four times during day 1 and daily during days 2-15. all abnormalities were recorded
General Behaviour
Nose
Respiration
Eye
Motility
Body position
Motor susceptibility
Skin
Various - Statistics:
- The LOGIT-Model could not applied to the observed rate of death. The toxicity was estimated without use of a statistical model.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No dead recorded
- Clinical signs:
- other: The rats exhibited blackened skin throughout the entire study period. No systemic signs were observed in any animals
- Other findings:
- Macroscopical findings: no findings noted nor in males, nor in females.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The toxicity of test substance was estimated to be greater than 2000 mg/kg
- Executive summary:
Test substance was tested for oral acute toxicity according to OECD guideline 402.
A singular dose of 2000 mg/kg was administrated by semiocclusive coverage to rat HanIbm: WIST (SPF).
Result
No dead recorded
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