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Diss Factsheets
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EC number: 939-513-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- between 1999-01-20 and 1999-01-22
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to an appropriate national standard method. It was compliant with GLP however no analytical monitoring was carried out.
- Qualifier:
- according to guideline
- Guideline:
- other: ISO TC147SC5/WG2 "Water quality, determination of acute lethal toxicity to marine copepods (Copepoda crustacea)".
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: 400 mg of test material (= 200 mg active ingredient) was dissolved in synthetic sea water and the volume adjusted to 2 L to give the 100 mg active ingredient (ai)/L test concentration. Aliquots of this concentration were separately dispersed in synthetic sea water and the volume adjusted to 1 L to give the remaining test concentrations. - Test organisms (species):
- other aquatic arthropod: Acartia tonsa
- Details on test organisms:
- TEST ORGANISM
- Source: Guernsey Sea Farms Ltd, Parc Lane, Vale, Guernsey, UK
- Age at study initiation (mean and range, SD): stage 5, adults
- Method of breeding: not reported
- Feeding during test: none
ACCLIMATION
- Acclimation period: not reported
- Acclimation conditions (same as test or not): same temperature and salinity as study
- Type and amount of food: mixed culture of marine algae
- Feeding frequency: not reported
- Health during acclimation (any mortality observed): not reported - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Test temperature:
- 21⁰C
- pH:
- range: 6.4 to 8
- Dissolved oxygen:
- 5.9 to 6.3 mg O2/L
- Nominal and measured concentrations:
- Nominal concentrations: 1.8, 3.2, 5.6, 10, 18, 32, 56 and 100 mg active ingredient (ai)/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: jars
- Material, size, fill volume: 50 ml glass jars filled with 25 ml solution
- Aeration: none
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: the test water was prepared using a commercially available formulation, manufactured by Dr Biener GmbH, Aquarientechnik, 36367 Wartenberg, Germany and supplied by CJ Skilton, Chelmsford, UK.
- Culture medium different from test medium: yes
- Intervals of water quality measurement: temperature was recorded throughout
OTHER TEST CONDITIONS
- Adjustment of pH: not reported
- Photoperiod: 16 h light: 8 h darkness with 20 mi dusk and dawn transition periods
- Light intensity: not reported
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : the number of immobile animals were recorded after 24 and 48 hours.
TEST CONCENTRATIONS
- Spacing factor for test concentrations: ca. 1.8
- Range finding study
- Test concentrations: 0.01 to 100 mg/l
- Results used to determine the conditions for the definitive study: no mortalities were observed at test concentrations up to 10 mg a.i./L. However, mortalities were observed at 100 mg a.i./L. - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 64 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Remarks:
- acid
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% CL 55-75 mg a.i./L
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 82 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Remarks:
- acid
- Basis for effect:
- mobility
- Remarks on result:
- other: 95 % CL 64-104
- Results with reference substance (positive control):
- - Results with reference substance valid? yes
- EC50/LC50: 6.2 mg/l - Reported statistics and error estimates:
- The LC50 was determined by the moving average method of Thompson (1947)
- Validity criteria fulfilled:
- yes
- Conclusions:
- A 48h EC50 value of 64 mg active acid/L has been reported for the effects of the test substance on the mobility of the freshwater copepod Acartia tonsa based on nominal concentrations.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to Annex 3 of the CSR or IUCLID Section 13 for justification of read-across within the HEBMP category.
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 64 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Remarks:
- active acid
- Basis for effect:
- mortality
- Remarks on result:
- other: 95% CL 55-75 mg a.i./L
Referenceopen allclose all
Table 1. Summary of findings.
Nominal concentrations (mg a.i./L) | Mortalities (%) | |
24 h | 48 h | |
Control | 0 | 0 |
1.0 | 0 | 0 |
1.8 | 0 | 0 |
3.2 | 0 | 0 |
5.6 | 0 | 0 |
10 | 0 | 0 |
18 | 0 | 0 |
32 | 0 | 0 |
56 | 20 | 35 |
100 | 70 | 90 |
Description of key information
No data are available for the registration substance. A reliable test result of 48 hour EC50 64 mg/L, A. tonsa, nominal concentrations of active acid is available for the HEBMP-H. The result is read-across to HEBMP-xNa.
Key value for chemical safety assessment
Marine water invertebrates
Marine water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- 64 mg/L
Additional information
- HEBMP is present as HEBMP-H or one of its ionised forms. The degree of ionisation depends upon the pH of the mediaand not whether HEBMP-xNa salt, HEBMP-H (acid form), or another salt was used for dosing.
- Disassociated sodium cations. The amount of sodium present depends on which salt was added.
- It should also be noted that divalent and trivalent cations would preferentially replace the potassium ions. These would include calcium (Ca2+), magnesium (Mg2+) and iron (Fe3+).
A 48-hour EC50 value of 64 mg active acid/L has been reported for the effects of HEBMP acid on the mobility of the marine copepod Acartia tonsa based on nominal concentrations. This result is interpreted as 64 mg/l as active acid. Whilst the proportion of cyclic and linear constituents was not measured for the tested sample, it is conservatively interpreted that the cyclic constituent could have been present at ca. 50% w/w.
The acid and sodium salts in the HEBMP category are freely soluble in water. The HEBMP anion can be considered fully dissociated from its sodium cation when in dilute solution. Under any given conditions, the degree of ionisation of the HEBMP species is determined by the pH of the solution. At a specific pH, the degree of ionisation is the same regardless of whether the starting material was HEBMP-H, HEBMP-xNa, or another salt of HEBMP.
Therefore, when a salt of HEBMP is introduced into test media or the environment, the following is present (separately):
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