Registration Dossier
Registration Dossier
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EC number: 213-969-1 | CAS number: 1070-10-6
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Testing is not scientifically justified as this substance is hydrolytically unstable and the decomposition products have a low potential for aquatic bioaccumulation and a low potential to cross biological membranes. Acute toxicity (96-h LC50) of the main decomposition product 2-ethylhexanol is used as a key value.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 17.1 mg/L
Additional information
When this substance comes in contact with water or moisture, a complete hydrolysis will take place with no significant reaction products other than 2-ethylhexanol and hydrated titanium dioxide (half-life < 10 minutes, Brekelmans M.J.C. 2013). The organic decomposition product 2-ethylhexanol is readily biodegradable and not persistent based on the log Kow value of 2.9. The CSA indicates that toxicity of this substance is similar to the main degradation product 2-ethylhexanol. Key studies (short-term toxicity to daphnia and algae) conducted for the analogue category member (titanium tetra(octanolate), branched and linear, CAS 68526 -83 -0) justify that these organometallic titanates hydrolyse during toxicity testing and the aquatic toxicity is similar to the alcohol released in water. Category and read-across justifications are presented in the annexes of the CSR.
Therefore, and for reasons of animal welfare, a short-term toxicity study on fish is unjustified, and the key value for CSA is obtained from the studies conducted for 2 -ethylhexanol.
According to Scholz 1991, the 96 -h LC50 (mortality) of 2 -ethylhexanol to Leuciscus idus melanotus is 17.1 mg/L conducted according to EEC 84/44 similar to OECD test guideline 203 based on measured concentrations. According to Geiber et al. 1985, The 96 -h LC50 (mortality) of 2 -ethylhexanol to Pimephales promelas is 28.2 mg/L conducted by using a method similar to OECD test guideline 203 based on measured concentrations. Both these studies are considered as reliable for C&L purposes, and the lowest value is selected as a key value for CSA.
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