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EC number: 407-430-1 | CAS number: 3741-80-8 CP22595; SANTOCURE TBS1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to US EPA and EU protocol. Minor deviations from animal housing and care AAALAC standards were reported, but were considered to have had no effect on the oucome of this study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: US EPA-TSCA 40 CFR Part 798 section 798.1100
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EEC No° L 251/94
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- N-(1,1-dimethylethyl)bis(2-benzothiazolesulfen)amide
- EC Number:
- 407-430-1
- EC Name:
- N-(1,1-dimethylethyl)bis(2-benzothiazolesulfen)amide
- Cas Number:
- 3741-80-8
- Molecular formula:
- C18H17N3S4
- IUPAC Name:
- bis(1,3-benzothiazol-2-ylsulfanyl)(tert-butyl)amine
- Details on test material:
- - Name of test material (as cited in study report): CP-22595
- Physical state: off white powder
- Analytical purity: 89.0 - 93.3%
- Purity test date: 21 December 1989 and 06 April 1990.
- Lot/batch No.: 4064285
- Stability under test conditions: confirmed by HPLC experiment
- Storage condition of test material: room temperature
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Mohican Valley Trabbitry, Loudonville, Ohio
- Age at study initiation: young adult
- Weight at study initiation: ca 2.1 kg
- Housing: individually housed in suspended stainless steel cages in an environment-controlled room
- Diet (e.g. ad libitum): Agway Prolab Rabbit Ration, ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: minimum 5 days
- Animal identification: metal ear tags and cage cards
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 61-70°F (= ca. 16-21°C)
- Humidity (%): 40-60%
- Air changes (per hr): not specified
- Photoperiod (hrs dark / hrs light): 12-hour light/dark cycle
On the day prior to dosing, the fur was clipped from the dorsal area of the trunk of each animal using small animal clippers. Care was taken during clipping to avoid accidental abrasion to the skin.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 20x12cm
- % coverage: approximately 10% of the animal's total body surface
- Type of wrap if used: 8-ply gauze dressing covered with plastic wrap + tubular stockinette sleeve
REMOVAL OF TEST SUBSTANCE
- Washing (if done): rinsing with distilled water
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2000 mg/kg bw
- Concentration (if solution): not applicable
- Constant volume or concentration used: yes
- For solids, paste formed: test substance was moistened at dosing with distilled water at a ratio of 0.1 mL/0.1 g in order to enhance test substance contact with the skin.
VEHICLE
- Amount(s) applied (volume or weight with unit): 0.1 mL water / 0.1g test substance
- Concentration (if solution): not applicable
- Lot/batch no. (if required): not applicable
- Purity: - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days (or other?): 15 days
- Frequency of observations and weighing: observation: daily; weighing: weekly
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
- Preliminary study:
- Range-finding study: male and female rabbits received a single dermal application of the test substance at the following levels:
500, 1000, 1500 and 2000 mg/kg bw.
Exposure period: 24 hours.
Following dosing, the animals were observed for mortality for eight consecutive days. No deaths occurred.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred during this study.
- Clinical signs:
- other: The most notable clinical signs consisted of transient incidences of diarrhea, soft stools, fecal stains and mild erythema at the dermal test sites.
- Gross pathology:
- Internal observations at necropsy consisted of mottled lungs in 2/10 animals. This pulmonary change may have resulted from the method of sacrifice (T61 euthanasia solution).
Applicant's summary and conclusion
- Interpretation of results:
- other: EU GHS criteria not met
- Conclusions:
- Under the conditions of this test, the acute dermal LD50 of the test substance was determined to be greater than 2000 mg/kg bw in the rabbit.
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