Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-921-8 | CAS number: 111-92-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data only given as summary tables but acceptable for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 954
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Single oral dose toxicity is estimated by the gastric intubation of groups of five non-fasted, male rats four to five weeks of age and 90 to 120 grams. The dosages are arranged in a logarithmic series differing by a factor of two. The most probable LD50 value and its fiducial range are estimated by the method of Thompson.
- GLP compliance:
- no
- Remarks:
- predating GLP
- Limit test:
- no
Test material
- Reference substance name:
- Dibutylamine
- EC Number:
- 203-921-8
- EC Name:
- Dibutylamine
- Cas Number:
- 111-92-2
- Molecular formula:
- C8H19N
- IUPAC Name:
- N-butylbutan-1-amine
- Details on test material:
- Di-n-butylamine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Carworth-Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: own breeding
- Age at study initiation: 4 - 5 w
- Weight at study initiation: 90 - 120 g
- Fasting period before study: unfasted
- Diet: Rockland rat diet
Administration / exposure
- Route of administration:
- oral: gavage
- Doses:
- No data; dosages were in a logartitmic series
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- moving average method according to Thompson (1947) and Weil (1952)
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 550 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no data
- Clinical signs:
- no data
- Body weight:
- no data
- Gross pathology:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The LD50 of the test substance after single oral administration was found to be 550 mg/kg bw in male rats.
- Executive summary:
The test article was administered to a group of 5 non-fasted male Carworth-Wistar rats by intubation of dosages in a logartithmic series. After 14 days of observation the LD50 was calculated to be 550 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
