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EC number: 254-809-0 | CAS number: 40137-22-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- 27 September 1993 and 2 November 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to OECD Guideline No 404 and in accordance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Aminopropandiol
- IUPAC Name:
- Aminopropandiol
- Reference substance name:
- 3-aminopropane-1,2-diol
- EC Number:
- 210-475-8
- EC Name:
- 3-aminopropane-1,2-diol
- Cas Number:
- 616-30-8
- IUPAC Name:
- 3-aminopropane-1,2-diol
- Reference substance name:
- 3-amino-1,2-propanediol
- IUPAC Name:
- 3-amino-1,2-propanediol
- Details on test material:
- - Name of test material (as cited in study report): Aminopropandiol
- Physical state - yellow, viscous, transparent liquid
- Batch Number - 1201-362-93
- Storage condition of test material: Refrigerated at 5°C
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rabbit
- Strain:
- other: SPF albino
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Mollegaard Breeding Centre Denmark
- Weight at study initiation: 2.5-2.8 kg
- Housing: singe PPL cages with perforated floor
- Diet (e.g. ad libitum): feed pellets "Altromin 2123" from Chr. Petersen A/S, DK-4100 Lille Skensved, ad libitum
- Water (e.g. ad libitum): drinking water acidified with hydrochloric acid to pH 2.5
- Acclimation period: one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): range of 18-24
- Humidity (%): 55 plus or minus 15
- Air changes (per hr): 10 times per hour
- Photoperiod (hrs dark / hrs light): 12 hours dark/12 hours light
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL
- Lot/batch no. (if required): 1201-362-93 - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1 hour
- Number of animals:
- 4
- Details on study design:
- TEST SITE
- Area of exposure: 10 x 10 cms on the back.
- Type of wrap if used: gauze secured with 1cm wide adhesive tape and fixed with Scanpor tape, 4.5 cms width loosely wound round the trunk
REMOVAL OF TEST SUBSTANCE
- Washing (if done): washed with soap and lukewarm water
- Time after start of exposure: 4 hours
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24, 48 72h
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks:
- 14d
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24, 48 72h
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7d
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 24, 48 72h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14d
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- other: 24, 48 72h
- Score:
- 1.83
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14d
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24, 48 72h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 24, 48 72h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 24, 48 72h
- Score:
- 2.67
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- other: 24, 48 72h
- Score:
- 0.5
- Max. score:
- 4
- Irritant / corrosive response data:
- At the reading one hour after termination of treatment very slight to well-defined erythema and oedema were observed in 3 rabbits while severe erythema and moderate to severe oedema were observed in one rabbit (no. 6585). The exposed skin of the last rabbit was also covered with small wounds.
At the following 24, 48 and 72 hour readings very slight to well-defined erythema and oedema were still observed in 3 rabbits. In one rabbit (6586) severe erythema and moderate oedema were observed. A dark brown to black inelastic crust was observed covering the exposed skin site at the 24, 48 and 72 hour readings.
On day 7 the skin appeared normal in one rabbit (6585) while scattered white scales with intact skin underneath were observed in another rabbit (6584). In rabbit 6587 a small wound (about 1 x 0.5 cm) was seen on the left skin site. Scattered white scales were seen covering the test sites of this rabbir. A black inelastic crust was seen at both sites in rabbit 6586.
On day 14 scar tissue measuring 1 x 0.5 cm was observed on the teft test site of rabbit 6587 indicating irreversible skin changes in this rabbit. A black crust undergoing demarcation was seen in rabbit 6586.
On day 21 the black crust covering the test site of rabbit 6586 were still undergoing demarcation.
On day 28 scar tissue was observed under the crusts of rabbit no 6586.
It was then concluded that aminopropandiol induced irreversible skin changes in two of the rabbits and the study was terminated.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- It was concluded that Aminopropandiol induces irreversible skin changes in two rabbits and the study was terminated. Aminopropandiol shall be classifed as corrosive.
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