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EC number: 915-741-3 | CAS number: 25618-55-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 July - 21 October 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study was performed according to OECD and EC guidelines and according to GLP principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Media:
- other: HPLC column
Test material
- Reference substance name:
- 1-(1,3-dihydroxypropoxy)propane-1,3-diol; 3-{3-[3-(2,3-dihydroxypropoxy)-2-hydroxypropoxy]-2-hydroxypropoxy}propane-1,2-diol; nonane-1,2,4,5,6,8,9-heptol
- EC Number:
- 915-741-3
- Cas Number:
- 25618-55-7
- Molecular formula:
- not applicable - multi-constituent substance
- IUPAC Name:
- 1-(1,3-dihydroxypropoxy)propane-1,3-diol; 3-{3-[3-(2,3-dihydroxypropoxy)-2-hydroxypropoxy]-2-hydroxypropoxy}propane-1,2-diol; nonane-1,2,4,5,6,8,9-heptol
- Reference substance name:
- Polyglycerol-3
- IUPAC Name:
- Polyglycerol-3
- Details on test material:
- - Name of test material (as cited in study report): Polyglycerol-3
- Substance type: organic liquid
- Physical state: Colourless to pale yellow viscous liquid
- Analytical purity:
27.9% Diglycerol
46.0% Triglycerol
17.9% Tetraglycerol
5.6% Pentaglycerol
2.6% Hexaglycerol and higher
- Purity test date: no data
- Lot/batch No.: RBA081008A
- Expiration date of the lot/batch: 31 May 2010
- Stability under test conditions: stabile
Constituent 1
Constituent 2
- Radiolabelling:
- no
Study design
- Test temperature:
- 35°C +/- 1°C
HPLC method
- Details on study design: HPLC method:
- Analytical conditions
Instrument: Acquity UPLC system (Waters, Milford, MA, USA)
Detector: ZQ 2000 mass spectrometer (Waters)
Acquity UPLC TUV detector (Waters)
Column: Hypersil BDS-CN, 100 mm x 2.1 mm i.d., dp = 3 µm (Thermo, San Jose, CA, USA)
Column temperature: 35°C +/- 1°C
Mobile phase neutral pH: 30/70 (v/v) methanol/water
Flow: 0.2 ml/min
Injection volume: 10 µl
Post column addition: 30 mM ammonium hydroxide at a flow of 0.1 ml/min
UV detection: 210 nm
MS detection
Ionisation source: ESI+
Cone voltage: 20 V
Quantitation diglycerol: m/z 167.0 amu
Quantitation triglycerol: m/z 241.0 amu
Quantitation Ethylmethylketone: m/z 73.0 amu
Reference substance solution: A stock solution of Acetanilide at a concentration of 1.05 g/l in methanol was used. A dilution of this stock solution was prepared by adding 50 µl of the stock solution to a 5 ml volumetric flask. The flask was filled up to the mark with mobile phase. The blank solution was mobile phase.
Ethylmethylketone solution: A stock solution of Ethylmethylketone was prepared to determine the difference in retention time between the UV-detector and the MS-detector. The stock solution was prepared by adding 2000 µl Ethylmethylketone [99.9%; Sigma-Aldrich] to a 10 ml volumetric flask. The flask was filled up to the mark with mobile phase.
Test solution: A 2975 mg/l stock solution of the test substance was prepared in methanol. The test solution was prepared by adding 500 µl of the stock solution and 1167 µl water to a 5 ml volumetric flask. The flask was filled up to the mark with mobile phase. The final concentration of the test substance solution was 297.5 mg/l. The test substance blank solution was mobile phase.
Injections: The Acetanilide and test substance solutions were injected in duplicate. Blank solutions and the ethylmethylketone solution were analysed by single injection.
Results and discussion
Adsorption coefficientopen allclose all
- Type:
- Koc
- Value:
- < 10.82
- Type:
- log Koc
- Value:
- < 1.26
Results: HPLC method
- Details on results (HPLC method):
- In the chromatogram of the test substance solution recorded on the MS detector, one peak was observed at m/z 167.0 amu (diglycerol) and one at m/z 241.0 amu (triglycerol). Both peaks had a retention time of 1.55 minutes. Under the same analytical conditions, the retention time of acetanilide (log Koc = 1.26) was 2.18 minutes on the UV detector which is equivalent to a retention time of 2.27 minutes on the MS detector .
Because the major constituents in Polyglycerol-3 eluted before Acetanilide, it was concluded that the log Koc of Polyglycerol-3 at neutral pH is < 1.26 (Koc < 1.82 x 10^1).
Results: Batch equilibrium or other method
- Statistics:
- none
Any other information on results incl. tables
none
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- HPLC estimation method showed that the log Koc of Polyglycerol-3 at neutral pH is < 1.26 (Koc < 18.2).
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