Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 629-780-6 | CAS number: 1234694-02-0
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (28 d and 56 d) >= 1000 mg/kg dw for Eisenia fetida (OECD 222, read across)
Key value for chemical safety assessment
Additional information
No experimental data evaluating the toxicity of Fatty acids, C12-16 (even numbered) and C18- unsatd., methyl esters (CAS No. 1234694-02-0) to soil macroorganisms are available.Therefore, toxicity data from two structurally related analogue substances are used as read-across (methyl laurate (CAS No. 111-82-0) and methyl palmitate (CAS No. 112-39-0)) in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. All three substances are fatty esters esterified with methanol, containing fatty acid components with C-chain lengths of C12 (CAS No. 111-82-0), C16 (CAS No. 112-39-0) and C12-16 (even numbered) and C18 unsaturated (CAS No. 1234694-02-0), respectively. The log Kow values of these substances (> 5) indicate high adsorption potential to soil particles. Methyl laurate (CAS No. 111-82-0) exhibits the highest toxicity to aquatic organisms (Daphnia and algae) throughout the whole SCAE Me category, with EC50 and NOEC values < 1 mg/L. Therefore, methyl laurate is used as worst-case read across substance. Based on the above information and the fact that the target substance contains C12 fatty acids (40-50%) and C16 fatty acids (up to 15%) the use of data from methyl laurate and methyl palmitate as read-across for Fatty acids, C12-16 and C18 unsatd., methyl esters is considered justified.
The toxicity of methyl laurate (CAS No. 111-82-0) and methyl palmitate (CAS No. 112-39-0) to earthworms was evaluated by Winkelmann (2013) in tests performed according to OECD 222. In both studies, Eisenia fetida was exposed to the test substance for 56 days at a concentration of 1000 mg/kg dw (limit test). Mortality and growth were evaluated after 28 days whereas reproduction was evaluated after 56 days. After the exposure period, no effects on earthworm’s survival, reproduction or growth were observed, leading to NOEC values >= 1000 mg/kg dw.
Based on the results obtained for the structurally related category members (in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5), it can be concluded that Fatty acids, C12-16 (even numbered) and C18-unsatd., methyl esters (CAS No. 1234694-02-0)will not exhibit toxicity to soil macroorganisms.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
