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Diss Factsheets
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EC number: 206-059-0 | CAS number: 298-14-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Potassium hydrogencarbonate
- EC Number:
- 206-059-0
- EC Name:
- Potassium hydrogencarbonate
- Cas Number:
- 298-14-6
- Molecular formula:
- CH2O3.K
- IUPAC Name:
- potassium hydrogen carbonate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Wiga GmbH, Sulzfeld, Germany
- Age at study initiation: 4 - 7 weeks
- Weight at study initiation: male 95 - 105 g; female 100 g
- Fasting period before study: over night fasted
- Housing: individual in makrolon cages on bedding
- Diet: ad libitum, R 4 rat laboratory chow, Ssniff Versuchtier-Diäten GmbH, 4770 Soest/ Westfalen
- Water: ad libitum, tap water
- Acclimation period: 6 days
ENVIRONMENTAL CONDITIONS
- Temperature: 20 - 23 °C
- Humidity: 40 - 70 %
- Air changes (per hr): 10 per hour
- Photoperiod (hrs dark / hrs light): 12 hour dark/light cycle
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- - Concentration in vehicle: 100.0 mg/ml in aqua destillata
MAXIMUM DOSE VOLUME APPLIED: 20 ml/kg bw - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Clinical examination was performed 15 and 30 minutes, 1, 2, and 4 hours following dosing and once daily thereafter.
- Body weight measurements: on the day prior to application (study day -1), at the day of application (study day 0) and on day 7 and 14 after application.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: no animal died
- Mortality:
- 0/ 10 animals died
- Clinical signs:
- piloerection during the first 30 minutes after application in all animals
- Body weight:
- normal weight gains
- Gross pathology:
- no macroscopic findings at necropsy
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- On the basis of the results obtained after a single oral administration, the oral LD50 of the test article "Kaliumbikarbonat" (potassium hydrogencarbonate) was determined to be > 2000 mg/kg bw. No significant clinical signs, effects on body weight or gross pathological findings were observed.
No classification for acute oral toxicity is justified for test substance "Kaliumbikarbonat" (potassium hydrogencarbonate) according to Regulation (EC) No 1272/2008. - Executive summary:
In an acute oral toxicity study (limit test, equivalent to now deleted OECD guideline 401), 5 male and 5 female, fasted Sprague-Dawley rats were given a single oral dose of 2000 mg/kg bw of test substance “Kaliumbikarbonat” (potassium hydrogencarbonate) and observed for 14 days.
Oral LD50 Males and Females > 2000 mg/kg bw
No mortality occurred in this limit test. Except of piloerection during the first 30 minutes after application in all animals, there were no treatment related clinical signs, necropsy findings or changes in body weight.
In this study, test substance "Kaliumbikarbonat" (potassium hydrogencarbonate) is not an acute oral toxicant.
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