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Diss Factsheets
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EC number: 233-732-6 | CAS number: 10339-55-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
A Local Lymph Node Assay (LLNA, Remus & Dony, 2016) was performed using three groups of female mice (5 mice per group). The animals were treated with different concentrations of Ethyllinalool (25, 50 (w/v) and 100%) by topical application at the dorsum of each ear once daily on three consecutive days. A control group of five mice was treated with the vehicle (DMF) only. Five days after the first application, the mice were intravenously injected into a tail vein with radiolabelled thymidine, then sacrificed and the lymph nodes were pooled per animal. No relevant increase in ear weights were observed and no relevant erythema was observed. In this study, Stimulation Indicis (S.I.) of 1.7, 3.1, and 4.0 were determined with the test item at concentrations of 25, 50 and 100% in water-free DMF, respectively. A clear dose-response was derived. Ethyllinalool was found to be a skin sensitiser and an EC3 value of 48.2 % (w/v) was derived.
Supporting Human Information: a 30 % Ethyllinalool solution was not sensitising in a Human Maximization Test (RIFM 1975)
The substance is a skin sensitizer (EC3 = 48.2 % w/v).
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
- Migrated from Short description of key information:
Ethyllinalool is not a skin sensitizer and does not carry any of the chemical structural alerts known to be associated with respiratory sensitization. Furthermore, literature data on high exposed factory workers [Schubert HJ (2006) Skin diseases in workers at a perfume factory, Contact Dermatitis: 55: 81–83] or subjects undergoing aromatherapy [Schaller M, Korting HC (1995) Allergic airborne contact dermatitis from essential oils used in aromatherapy, Clinical and Experimental Dermatology 20: 143-145.] showed no indications or clinical signs usually related to respiratory sensitization.
Justification for classification or non-classification
Based on the available information, Ethyllinalool is considered as skin sensitiser. Therefore, the substance Ethyllinalool needs to be classified as sensitizer Cat. 1B according to the critiria outlined in Annex I of Guidance to Regulation (EC) No. 1272/2008 Version 4.1, June 2015.
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