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Diss Factsheets
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EC number: 220-237-5 | CAS number: 2680-03-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: US OSHA Regulation: 29 CFR 1910.1200
- GLP compliance:
- not specified
- Test type:
- other: Inhalation Hazard Test
- Limit test:
- yes
Test material
- Reference substance name:
- N,N-dimethylacrylamide
- EC Number:
- 220-237-5
- EC Name:
- N,N-dimethylacrylamide
- Cas Number:
- 2680-03-7
- Molecular formula:
- C5H9NO
- IUPAC Name:
- N,N-dimethylacrylamide
- Details on test material:
- - Name of test material (as cited in study report): N,N-dimethylacrylamide
- Batch number: 7H147
- Physical state: clear colorless liquid
- Storage condition of test material: room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Sprague Dawley, Inc., Indianapolis, IN
- Age at study initiation: 4 weeks
- Weight at study initiation: 230-258 g (males), 175-213 g (females)
- Housing: one per suspended, wire bottom, stainless steel cage
- Diet: PMI Lab Diet Formula #5008, ad libitum except during the exposure period
- Water: Municipal water supply from automatic water systemn, ad libitum except during the exposure period
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22±3
- Humidity (%): 30-80
- Air changes (per hr): 10-12
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure chamber volume: 15.5 L
- Air flow: 5.66 L/min
- Method of holding animals in test chamber: polycarbonate tubes inserted in the body of the chamber
- Method of conditioning air: calibrated orifice plate at a rate of 21.9 air changes per hour
- Vapour generation: The vapor was generated by bubbling air through fritted tubes into 4 Erlenmeyer flasks, each containing 300 mL of the test substance. The air was heated prior to enrering tlasks by heating tape wrapped around the air tubes to approximately 35 °C. The vapor was pulled from the flasks through the exposure chamber.
TEST ATMOSPHERE
- Brief description of analytical method used: gas chromatography
- Samples taken from breathing zone: yes - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- gas chromatography
- Duration of exposure:
- 1 h
- Concentrations:
- 776 ppm (highest achievable vapour concentration at 35 ºC)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations were made frequently on day of exposure and at least once daily thereafter, body weights were recorded just prior to inhalation exposure and on days 7 and 14.
- Necropsy of survivors performed: yes - Statistics:
- In order to calculate a mean exposure, the Mean Value Theorem of Calculus was used to properly weigh the concentration, since the concentrations could not be measured continuously. This method weighs concentrations based on the time span of each concentration. A concentration can be calculated for each minute, which btter represents the exposure concentration received by each animal.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 776 ppm
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Remarks on result:
- other: original value, highest achievable vapour concentration at 35 ºC
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 3.16 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Mortality:
- There was no mortaIity during the study.
- Clinical signs:
- other: Fur coated with feces/urine was observed in all animals at 1 hour after exposure. For the remainder of the study, all animals appeared normal.
- Body weight:
- Body weight gain of surviving animals was unaffected by the administration of the test substance.
- Gross pathology:
- The gross necropsy conducted on each animal at termination of the study revealed no observable abnormalities, except for red lungs in three females.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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